Product
NeuroMab™ Anti-HMGB1 Antibody,Clone NR3753P
[CAT#: NRP-0422-P1789]
Functional antibody against Human HMG1
- Host Species:
- Human
- Species Reactivity:
- Human
- Applications:
- ELISA; Inhib; In Vitro; In Vivo
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The antibody screened from human Fab phage display library, and specifically binds HMG1 with high affinity. The high affinity antibody is a diagnostic antibody useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Human
Clone Number
NR3753P
Applications
ELISA; Inhib; In Vitro; In Vivo
Relevant Diseases
Neuroinflammation
Product Properties
Formulation
PBS only
Preservatives
BSA Free
Concentration
1mg/mL
Purification
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Purity
> 95% (SDS-PAGE)
Endotoxin Level
Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg
Low Endotoxin < 1 EU/mg
Shipping
Gel Packs
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Research Use Only
For research use only
Target
Product Pictures
ELISA
Figure 1 Binding kinetics and specificity of human anti-HMG1 antibodies.
HMG1 capture ELISA binding curves of several human anti-HMG1 antibodies demonstrate that these antibodies have different affinities for recombinant HMG1 produced in E. coli.
Inhib
Figure 2 A number of human anti-HMG1 antibodies inhibited HMG1-stimulated cytokine release from human PBMCs.
Inhib
Figure 3 Several human anti-HMG1 antibodies inhibit HMG1-stimulated cytokine gene expression in mouse macrophages (mMO).
Block
Figure 4. A subset of human anti-HMG1 antibodies block the binding of recombinant HMG1 to RAGE.
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
Kits
For Research Use Only. Not For Clinical Use.
