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Creative Biolabs
Product

NeuroMab™ Anti-HMG1 BBB Shuttle Antibody,Clone NR2803P

[CAT#: NRZP-1022-ZP3161]

Host Species:
Human
Species Reactivity:
Human
Applications:
ELISA; Inhib; In Vitro; In Vivo

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Clone Number

NR2803P

Applications

ELISA; Inhib; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

HMGB1

Official Name

HMGB1

Full Name

High-mobility group box 1

Alternative Names

HMGB1; High-mobility group box 1
Product Pictures
ELISA

Figure 1 Binding kinetics and specificity of human anti-HMG1 antibodies.

HMG1 capture ELISA binding curves of several human anti-HMG1 antibodies demonstrate that these antibodies have different affinities for recombinant HMG1 produced in E. coli.

Inhib

Figure 2 A number of human anti-HMG1 antibodies inhibited HMG1-stimulated cytokine release from human PBMCs.

Inhib

Figure 3 Several human anti-HMG1 antibodies inhibit HMG1-stimulated cytokine gene expression in mouse macrophages (mMO).

Block

Figure 4. A subset of human anti-HMG1 antibodies block the binding of recombinant HMG1 to RAGE.

IHC

Figure 5 HMG1 staining pattern in human brain tissue from multiple sclerosis (MS) specimens.

Specific HMGB1 staining of the cytoplasm of the microglia and the interstitia of an MS Plaque with Activated Microglia using 1 μg/ml G16.

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