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Creative Biolabs
Product

NeuroMab™ Anti-Tau BBB Shuttle Antibody, Clone ACI-36-3A8-Ab1

[CAT#: NRZP-1022-ZP3091]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB; IHC; In Vitro; In Vivo

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

ACI-36-3A8-Ab1

Applications

WB; IHC; In Vitro; In Vivo
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

Tau

Official Name

MAPT

Full Name

Tau Protein

Alternative Names

MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40
Product Pictures
IHC

Figure 1 shows antibody binding to phosphorylated Tau in AD and tau disease patient brain slices using the ACI-36-3A8-Ab1 antibody using TAUPIR.

FuncS

Figure 2 shows the effect of anti-Tau antibody treatment after a 1-week in vivo study of the pTau epitope pT231 using MSD.

FuncS

Figure 3 shows the effect of anti-Tau antibody treatment after a 1-week in vivo study of the pTau epitope pT231 using MSD.

WB

Figure 4 shows the pTau epitope western blot after anti-Tau antibody treatment in a 1-month in vivo study.

WB

Figure 5 shows pTau epitope western blot results after anti-Tau antibody treatment in a 3-month in vivo study.

WB

Figure 6 shows the pTau epitope western blot after anti-Tau antibody treatment for a 3-month in vivo study using biGT biomouse.

WB

Figure 7 shows pTau epitope Western blot results after anti-Tau antibody treatment for a 3-month in vivo study using biGT biomouse.

WB

Figure 8 shows pTau epitope western blot results after anti-Tau antibody treatment for a 3-month in vivo study using biGT biomouse.

FuncS

Figure 9 shows IHC after anti-Tau antibody treatment by ACI-36-2B6-Ab1 in a 3-month in vivo study.

FuncS

Figure 10 shows IHC following anti-Tau antibody treatment with ACI-36-2B6-Ab1 in a 3-month in vivo study.

FuncS

Figure 11 shows the Morris water maze results after ACI-36-2B6-Ab1 anti-Tau antibody treatment in a 3-month in vivo study.

FuncS

Figure 12 shows the Morris water maze results after ACI-36-3A8-AM anti-Tau antibody treatment in a 3-month in vivo study.

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