Product

Human CHO-K1/CXCR3/Gα15 Stable Cell Line

[CAT#: NCL20120043CR]

Human chemokine (C-X-C motif) receptor 3 (CXCR3A) Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: CHO-K1; GPCR Cell

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Product Overview

Description

Chemokine receptor 3 (CXCR3) belongs to the CXC chemokine receptor family. Similar to other chemokine receptors, it is a G protein-coupled receptor (GPCR). CXCR3 has two distinct splice variants, CXCR3A and CXCR3B, demonstrating different binding affinities. CXCR3-A binds to the CXC chemokines CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (ITAC) while CXCR3-B can also bind to CXCL4 in addition to CXCL9, CXCL10, and CXCL11.

Cell Types

CHO-K1; GPCR Cell

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 3 μg/ml puromycin, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

CXCR3

Family

Chemokine receptor

Strain

CXCR3/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

CD183

Official Name

CXCR3

Full Name

Chemokine (C-X-C motif) receptor 3

Alternative Names

GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R

Gene ID

2833(Human)

Uniprot ID

P49682(Human)

References

1. Liu, Z., Zhou, Y., Du, L., & Li, M. (2015). Novel intramolecular photoinduced electron transfer-based probe for the Human Ether-a-go-go-Related Gene (hERG) potassium channel. Analyst, 140(24), 8101-8108. 2. Zhang, W., Chen, L., Ma, Z., Du, L., & Li, M. (2014). Design, synthesis and biological evaluation of naphthalimidebased fluorescent probes for α1-adrenergic receptors. Drug Discoveries & Therapeutics, 8(1), 11-17.

Publications