Human CHO-K1/5-HT4/Gα15 Stable Cell Line

[CAT#: NCL20120006CR]

5-HT4 Serotonin Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: CHO-K1; GPCR Cell

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Product Overview

Description

5-HT4 is a human serotonin G protein-coupled receptor. Several studies suggested that intact 5-HT systems are important determinants of sensitivity and/or tolerance to ethanol-induce ataxia hypothermia. Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT receptor knock-out mice. Neuropsychiatric disorders such as anxiety, depression, migraine, vasospasm and epilepsy may involve different subtypes of the 5-HT receptor.

Cell Types

CHO-K1; GPCR Cell

Applications

GPCR Screening

Research Areas

GPCR; Neural Signal Transduction

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 400 μg/ml G418, 200 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

HTR4

Family

5-Hydroxytryptamine receptor

Strain

5-HT4/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

5-HT4

Official Name

5-HT4

Full Name

5-hydroxytryptamine (serotonin) receptor 4

Alternative Names

5-HT4 receptor; 5-HT4; 5-hydroxytryptamine (serotonin) receptor 4; 5-HT-4; 5-HT4 receptor (two splicing variants L and S); 5-hydroxytryptamine receptor 4; serotonin receptor 4; 5 hydroxytryptamine (serotonin) receptor 4

Gene ID

3360(Human); 15562(Mouse); 25324(Rat)

Uniprot ID

Q13639(Human); P97288(Mouse); Q62758(Rat)

References

1. Yang, I., Fortin, M. C., Richardson, J. R., & Buckley, B. (2011). Fused-core silica column ultra-performance liquid chromatography-ion trap tandem mass spectrometry for determination of global DNA methylation status. Analytical biochemistry, 409(1), 138-143.

Publications