Product
Human CHO-K1/5-HT2C Stable Cell Line
[CAT#: NCL20120004CR]
5-HT2C Serotonin Receptor Stable Cell Line
- Species:
- Human
- Applications:
- GPCR Screening
- Cell Types:
- CHO-K1; GPCR Cell
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Overview
Description
5-Hydroxytryptamine is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal, and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT (Hoyer et al., 1994). 5-HT2A which couples to Gq/11 is expressed throughout the central nervous system in the neocortex and olfactory tubercle. 5-HT2A receptor agonists may have important clinical value in the treatment of various disorders, such as depression, anxiety, bipolar disorder, and schizophrenia.
Cell Types
CHO-K1; GPCR Cell
Applications
GPCR Screening
Research Areas
GPCR; Neural Signal Transduction
Species
Human
Properties
Size
>1x10^6 Cells
Form
Frozen cells
Culture Medium
Ham's F12, 10% FBS, 400 μg/ml G418
Freeze Medium
45% culture medium, 45% FBS, 10% DMSO
Receptor
5-HT2C/HTR2C
Family
5-Hydroxytryptamine receptor
Strain
5-HT2C Cell Line
Cell Purity
>95%
Shipping
Dry ice
Storage
Liquid nitrogen immediately upon delivery
Handling Advice
Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
repeated exposure.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Warnings
Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.
Target Details
Target
5-HTR2C
Official Name
5-HTR2C
Full Name
5-hydroxytryptamine (serotonin) receptor 2C
Alternative Names
5-HT2C receptor; 5-HT1C; HTR1C; 5-HT2C; 5-hydroxytryptamine (serotonin) receptor 2C; 5-HTR2C; 5HT-1C; 5-HT-1C; 5-HT1C; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C; serotonin 1c receptor; serotonin receptor 2C; 5-HT2C receptor; 5-HT2cR; 5HT1c; SR1
Gene ID
3358(Human)
Uniprot ID
P28335(Human)
References
1. Mi, G., Liu, S., Zhang, J., Liang, H., Gao, Y., Li, N.,.. & Yang, Z. (2017). Levo-tetrahydroberberrubine produces anxiolytic-like effects in mice through the 5-HT 1A receptor. PloS one, 12(1), e0168964.
Publications
Publications (0)
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
