Human CHO-K1/5-HT2C Stable Cell Line

[CAT#: NCL20120004CR]

5-HT2C Serotonin Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

5-Hydroxytryptamine is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal, and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT (Hoyer et al., 1994). 5-HT2A which couples to Gq/11 is expressed throughout the central nervous system in the neocortex and olfactory tubercle. 5-HT2A receptor agonists may have important clinical value in the treatment of various disorders, such as depression, anxiety, bipolar disorder, and schizophrenia.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Signal Transduction

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 400 μg/ml G418

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

5-HT2C/HTR2C

Family

5-Hydroxytryptamine receptor

Strain

5-HT2C Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

5-HTR2C

Official Name

5-HTR2C

Full Name

5-hydroxytryptamine (serotonin) receptor 2C

Alternative Names

5-HT2C receptor; 5-HT1C; HTR1C; 5-HT2C; 5-hydroxytryptamine (serotonin) receptor 2C; 5-HTR2C; 5HT-1C; 5-HT-1C; 5-HT1C; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C; serotonin 1c receptor; serotonin receptor 2C; 5-HT2C receptor; 5-HT2cR; 5HT1c; SR1

Gene ID

3358(Human)

Uniprot ID

P28335(Human)

References

1. Mi, G., Liu, S., Zhang, J., Liang, H., Gao, Y., Li, N.,.. & Yang, Z. (2017). Levo-tetrahydroberberrubine produces anxiolytic-like effects in mice through the 5-HT 1A receptor. PloS one, 12(1), e0168964.

Publications