Human CHO-K1/5-HT2A Stable Cell Line

[CAT#: NCL20120002CR]

5-HT2A Serotonin Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

5-Hydroxytryptamine is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal, and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT (Hoyer et al., 1994). 5-HT2A which couples to Gq/11 is expressed throughout the central nervous system in the neocortex and olfactory tubercle. 5-HT2A receptor agonists may have important clinical value in the treatment of various disorders, such as depression, anxiety, bipolar disorder, and schizophrenia.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 400μg/ml G418

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

5-HT2A/HTR2A

Family

5-Hydroxytryptamine receptor

Strain

5-HT2A Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

5-HT2A

Official Name

HTR2A

Full Name

5-hydroxytryptamine (serotonin) receptor 2A

Alternative Names

5-HT2A receptor; 'D' receptor; HTR2; 5-HT2A; 5-hydroxytryptamine (serotonin) receptor 2A; 5Ht-2; 5-HT-2; 5-HT-2A; 5-hydroxytryptamine receptor 2A; serotonin 5HT-2 receptor; serotonin 5HT-2 receptor gene; serotonin receptor 2A; 5-HT2A receptor; Htr-2

Gene ID

3356(Human); 15558(Mouse); 29595(Rat)

Uniprot ID

P28223(Human); P35363(Mouse); P14842(Rat)

References

1. Mi, G., Liu, S., Zhang, J., Liang, H., Gao, Y., Li, N.,.. & Yang, Z. (2017). Levo-tetrahydroberberrubine produces anxiolytic-like effects in mice through the 5-HT 1A receptor. PloS one, 12(1), e0168964.

Publications