Product

Human CHO-K1/5-HT2B Stable Cell Line

[CAT#: NCL20120003CR]

5-HT2B Serotonin Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: CHO-K1; GPCR Cell

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Product Overview

Description

5-Hydroxytryptamine is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal, and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT (Hoyer et al., 1994). 5-HT2A which couples to Gq/11 is expressed throughout the central nervous system in the neocortex and olfactory tubercle. 5-HT2A receptor agonists may have important clinical value in the treatment of various disorders, such as depression, anxiety, bipolar disorder, and schizophrenia.

Cell Types

CHO-K1; GPCR Cell

Applications

GPCR Screening

Research Areas

GPCR; Neural Stem Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 200 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

5-HT2B/HTR2B

Family

5-Hydroxytryptamine receptor

Strain

5-HT2B Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

5-HT2B

Official Name

HTR2B

Full Name

5-hydroxytryptamine (serotonin) receptor 2B

Alternative Names

5-HT2B receptor; 5-HT2F; 5-HT(2B); 5-HT2B; 5-hydroxytryptamine (serotonin) receptor 2B; 5-HT-2B; 5-HT-2F; 5-hydroxytryptamine receptor 2B; serotonin receptor 2B; stomach fundus serotonin receptor; AJ012488; AV377389

Gene ID

3357(Human)

Uniprot ID

P41595(Human)

References

1. Deng, Z., Cheong, J. H., Caranica, C., Wu, L., Qiu, X., Judge, M. T.,.. & Arsenault, S. (2019). Single Cells of Neurospora Crassa Show Circadian Oscillations, Light Entrainment, Temperature Compensation, and Phase Synchronization. IEEE Access, 7, 49403-49417.

Publications