NeuroMab™ Anti-Amyloid Beta 1-15 Antibody, Clone mAb258

Product Overview

Description

mAb 258 (a) binds (i) wild-type Aβ 42/40 protofibril comprising N-terminal truncated Aβ forms and (ii) Aβ 42/40 Arc protofibril comprising N-terminal truncated Aβ forms and (b) has no or little cross-reactivity to Aβ 42/40 monomers. The antibody is useful for treating Alzheimer's disease.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

mAb258

Applications

WB; IHC; IP; ELISA

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

Amyloid Beta 1-15

Official Name

Amyloid Beta

Full Name

Amyloid Beta

Alternative Names

APP; Aβ; Abeta; Amyloid β

Gene ID

351 (Human); 11820 (Mouse)

Uniprot ID

P05067 (Human); P12023 (Mouse)

Product Pictures

ELISA

Figure 1 Sandwich ELISA titration of 4 mAbs (258, 7E4, 4E11 and 10F7) against witA42 fibril concentration.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.