Aptamer Products
While monoclonal antibodies have long been the cornerstone of molecular recognition, their inherent production variability, immunogenicity, and limited chemical tractability present significant challenges in modern diagnostics, therapeutics, and research. Aptamers have emerged as a superior class of synthetic affinity reagents engineered to overcome these constraints. These structured, single-stranded DNA or RNA oligonucleotides, identified through a proprietary in vitro selection process (SELEX), are designed to fold into unique conformations that bind their targets with affinities and specificities often rivaling or exceeding those of antibodies. Their purely chemical synthesis ensures unparalleled batch-to-batch consistency, exceptional stability, and a unique amenability to precise site-specific modification, establishing them as the definitive affinity tool for next-generation applications.
Fig.1 Aptamer 3D Structure and Target Binding.1
Why Choose Creative Biolabs?
Our comprehensive expertise and proprietary platforms make us the ideal partner for your aptamer-based projects. We offer an integrated, end-to-end solution that covers every stage of aptamer development, ensuring you receive a reagent perfectly tailored to your needs.
1. Unrivaled Custom Discovery and Selection: We don't believe in a one-size-fits-all approach. Our process begins with our AptaLib™ service, generating diverse, high-complexity aptamer libraries that form the foundation for successful discovery. From there, our specialized screening platforms are deployed based on your target type:
- ProApta™: For high-affinity aptamer discovery against protein targets.
- CellApta™: Utilizing advanced technology for the identification of aptamers that recognize specific cell-surface markers.
- SmolApta™: Designed to overcome the challenges of finding binders for small molecules.
- MetApta™: Focused on the precise detection of specific metal ions.
2. Advanced Engineering and Tailored Modifications: A powerful aptamer is one that integrates seamlessly into your application.
Our BiApta™ bispecific aptamer engineering service allows for the creation of novel constructs with dual-target functionality. Furthermore, through our AptaMod™ platform, we provide a vast array of tailored aptamer modifications. Whether you require conjugation to fluorophores for imaging, biotin for immobilization, or nanoparticles for drug delivery, we can functionalize your aptamer for optimal performance.
3. Guaranteed Quality and Scalable Synthesis: As synthetic molecules, aptamers bypass the biological variability of antibodies.
Our AptaSyn™ custom synthesis platform ensures the highest purity and unparalleled batch-to-batch consistency. Every aptamer we produce undergoes rigorous quality control and validation, guaranteeing reliable performance in your hands, from small-scale research to large-scale manufacturing.
Applications of Aptamers
The unique advantages of aptamers have unlocked new possibilities across a wide spectrum of scientific disciplines. At Creative Biolabs, we develop aptamers that are empowering innovation and driving progress in:
- Diagnostics: Aptamers' robustness and specificity make them ideal for developing next-generation biosensors, lateral flow assays, and ELISA-like kits. Their stability allows for reliable performance even in point-of-care and field settings where environmental conditions can be harsh.
- Therapeutics: With their low immunogenicity and small size, aptamers are excellent candidates for targeted therapies. They can be engineered to deliver drug payloads directly to diseased cells, act as antagonists to block protein function, or serve as in vivo imaging agents.
- Basic and Applied Research: In the lab, aptamers are transforming fundamental techniques. They serve as superior ligands for affinity chromatography, reliable probes in Western blotting and flow cytometry (FACS), and essential components in complex molecular assemblies.
- Food Safety & Environmental Monitoring: The ability to generate aptamers against toxins, pesticides, and pathogens enables the rapid, specific, and cost-effective detection of contaminants, ensuring global safety and compliance.
Our Aptamer Screening Workflow
To learn more about our aptamer products, please contact us today.
Reference
- Arshavsky-Graham, Sofia et al. "Aptasensors versus immunosensors-Which will prevail?." Engineering in life sciences vol. 22,3-4 319-333. 13 Jan. 2022, doi:10.1002/elsc.202100148. Distributed under Open Access License CC BY 4.0 without modification.
Target


Aptamer designed to specifically recognize DISC1, a scaffolding protein implicated as a major risk factor for schizophrenia and other psychiatric disorders.

Aptamer designed to specifically recognize Complement C4-A, a key immune protein whose genetic variations are linked to schizophrenia.

Aptamer designed to specifically recognize the GluN2A subunit of the NMDA receptor, a key protein in synaptic plasticity and epilepsy.

Aptamer designed to specifically recognize Progranulin, a growth factor and lysosomal protein linked to frontotemporal dementia.

Aptamer designed to specifically recognize the D2 Dopamine Receptor, a primary target for antipsychotic medications.

Aptamer designed to specifically recognize the 5-HT1A receptor, a key serotonin receptor and a major target for antidepressant and anxiolytic drugs.

Aptamer designed to specifically recognize Brain-Derived Neurotrophic Factor, a key neurotrophin involved in synaptic plasticity and neuronal survival.

Aptamer designed to specifically recognize Tissue-Type Plasminogen Activator, a key enzyme in the fibrinolytic system used to dissolve blood clots.

Aptamer designed to specifically recognize Vascular Endothelial Growth Factor A, a key signaling protein in angiogenesis and cancer.

Aptamer designed to specifically recognize Nrf2, the master regulator of the cellular antioxidant response.

Aptamer designed to specifically recognize TRPM2, a cation channel that acts as a key sensor for oxidative stress.

Aptamer designed to specifically recognize Neuroligin, a family of postsynaptic cell adhesion molecules implicated in autism and synaptic function.

Aptamer designed to specifically recognize Neurexin, a family of presynaptic cell adhesion molecules crucial for synapse function and implicated in autism.

Aptamer designed to specifically recognize Chromodomain-Helicase-DNA-Binding Protein 8, a key chromatin remodeler strongly linked to Autism Spectrum Disorder.

Aptamer designed to specifically recognize Methyl-CpG-Binding Protein 2, a key epigenetic reader implicated in Rett syndrome.

Aptamer designed to specifically recognize Metabotropic Glutamate Receptor 5, a key modulator of synaptic plasticity and a target for neurological disorders.

Aptamer designed to specifically recognize SHANK3, a master scaffolding protein at the synapse implicated in Autism Spectrum Disorder.

Aptamer designed to specifically recognize Interleukin-23, a heterodimeric cytokine central to the pathogenesis of Th17-mediated autoimmune diseases.

Aptamer designed to specifically recognize Myelin Basic Protein, a fundamental component of the myelin sheath and an autoantigen in Multiple Sclerosis.

Aptamer designed to specifically recognize Myelin Oligodendrocyte Glycoprotein, a key autoantigen in demyelinating neurological diseases.

Aptamer designed to specifically recognize Survival Motor Neuron 2 protein, the key therapeutic target for Spinal Muscular Atrophy (SMA).

Aptamer designed to specifically recognize Survival Motor Neuron 1 protein, the key protein deficient in Spinal Muscular Atrophy (SMA).

Aptamer designed to specifically recognize Protein C9orf72, a protein linked to the most common genetic cause of ALS and FTD.

Aptamer designed to specifically recognize RNA-Binding Protein FUS, a key protein implicated in Amyotrophic Lateral Sclerosis (ALS).

Aptamer designed to specifically recognize TAR DNA-Binding Protein 43, a key protein in the pathology of ALS and FTLD.

Aptamer designed to specifically recognize Superoxide Dismutase 1, a key antioxidant enzyme implicated in Amyotrophic Lateral Sclerosis (ALS).

Aptamer designed to specifically recognize the Kv7.2 potassium channel subunit, a key regulator of neuronal excitability implicated in epilepsy.

Aptamer designed to specifically recognize mTOR, a central kinase that regulates cell growth, proliferation, and metabolism.

Aptamer designed to specifically recognize the alpha-1 subunit of the GABA-A receptor, a key target in neuroscience and epilepsy research.

Aptamer designed to specifically recognize Sodium Channel Protein Type 1 Subunit Alpha (Nav1.1), a critical ion channel implicated in epilepsy.
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