Proteins & Peptides
Proteins and peptides are macromolecules that perform a multitude of vital functions, many of which are indispensable to life. These include cytokines, neurotrophins, growth factors, signaling proteins, viral and bacterial antigens, human immunoglobulins, and numerous other biological entities. With a wealth of knowledge in the field of neuroscience, we are certain that we can offer you a wide range of affordable, high-quality neuroproteins and peptides to help you expedite your drug development efforts for neurological disease targets.
Applications
- Physiological & Pathological Research
The causal relationship between pathogenic mutations and increased protein aggregation is a key feature of neurodegenerative diseases, such as those encoding amyloid precursor protein (AD), tau protein (AD), alpha-synuclein (PD), etc. We are delighted to provide a variety of active recombinant proteins for neurodegenerative disease research, assisting you to discover ways to prevent protein aggregation, facilitate precipitate clearance, or induce their recovery.
- In Vitro Modeling
Chronic neuroinflammation has been linked to the advancement of neurodegenerative disorders like Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Cytokines are a common stimulus that induces inflammation and can be employed to induce in vitro neuroinflammatory models. Cytokines activate related receptors, thereby initiating key intracellular signaling pathways. The following cytokines have been identified as key stimuli in neuroinflammatory processes: IFN-γ, IL-33, TNF-α, IL-1β, and IL-6.
- Enzyme Assay
Enzymes are essential proteins crucial for chemical processes and are employed extensively in the development of pharmaceuticals and biological research. Our product list contains a variety of proteins that can be used to initiate enzyme signaling, including from a variety of animal sources.
BBB Shuttle Proteins
Transcytosis is a phenomenon that occurs in a multitude of cell types. At Creative Biolabs, we employ receptor-mediated transcytosis (RMT) to develop engineered carriers (BBB shuttle proteins) to improve blood-brain barrier (BBB) crossing. The protein-based engineered carrier is expected to significantly enhance the ability of macromolecules to reach the brain, thereby accelerating central nervous system disease research.
Fig.1 Receptor-mediated transcytosis engineered BBB shuttle proteins.1
If the product you're looking for isn't listed, please contact us immediately. Our reagent experts will assist you in selecting the right product for your specific application. Kindly reach out to us via phone or email, and we will be happy to help you locate the ideal product for the task.
Reference
- Pulgar, Victor M. "Transcytosis to cross the blood brain barrier, new advancements and challenges." Frontiers in neuroscience 12 (2019): 418903.



- Species:
- Human
- Relevant Diseases:
- Neuroinflammation


- Species:
- Human
- Relevant Diseases:
- Parkinson's Disease


- Species:
- Human


- Species:
- Human
- Relevant Diseases:
- Atherosclerosis


- Species:
- Human
- Relevant Diseases:
- MPSIIIB


- Species:
- Human
- Relevant Diseases:
- Sanfilippo type A syndrome


- Species:
- Human
- Relevant Diseases:
- MLD


- Species:
- Human
- Relevant Diseases:
- Hunter's syndrome


- Species:
- Human


- Species:
- Human
- Relevant Diseases:
- Neuroinflammation


- Species:
- Human
- Relevant Diseases:
- Parkinson's Disease


- Species:
- Human


- Species:
- Human
- Relevant Diseases:
- Hurler's syndrome


- Species:
- Human
- Relevant Diseases:
- LSDs

Selectively promoting tau removal in tauopathies.
- Species:
- Human
- Relevant Diseases:
- Alzheimer's Disease
- NeuroMab™ Anti-Alpha Synuclein Antibody(NRP-0422-P614) (Cat#: NRP-0422-P614)
- NeuroMab™ Anti-SEZ6 Antibody(NRP-0422-P517) (Cat#: NRP-0422-P517)
- NeuroMab™ Anti-FGFR1 Antibody(NRP-0422-P1244) (Cat#: NRP-0422-P1244)
- NeuroMab™ Anti-SEZ6 Antibody(NRP-0422-P515) (Cat#: NRP-0422-P515)
- NeuroMab™ Anti-Amyloid Beta 1-15 Antibody(NRP-0422-P867) (Cat#: NRP-0422-P867)
- NeuroMab™ Anti-GARP Antibody(NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody(NRZP-1022-ZP4050) (Cat#: NRZP-1022-ZP4050)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P1686) (Cat#: NRP-0422-P1686)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P1760) (Cat#: NRP-0422-P1760)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Mouse Midbrain Dopaminergic Neuron Cell MN9D (Cat#: NCL2110P059)
- Human Microglia Cell Line HMC3, Immortalized (Cat#: NCL-2108P38)
- Human Brain Astroblastoma U-87 MG (Cat#: NCL2110P117)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Rat Immortalized Retinal Muller Cell Line rMC-1 (Cat#: NCL-2106-S93)
- Human Retinal Epithelial Cell ARPE-19 (Cat#: NCL2110P069)
- Mouse Glioma Cell Line GL261 (Cat#: NCL-2108P28)
- iNeu™ Human Neural Stem Cell Line (Cat#: NCL200552ZP)
- Rat Retinal Muller Cell Line, Immortalized (Cat#: NCL-21P6-192)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- pAAV-syn-jGCaMP8s-WPRE (Cat#: NTA-2106-P063)
- pAAV-syn-FLEX-jGCaMP8f-WPRE (Cat#: NTA-2106-P064)
- Dextran, NHS Activated, 40 kDa (Cat#: NRZP-0722-ZP124)
- rAAV-E-SARE-Cre-ERT2-PEST-WPRE-hGH polyA (Cat#: NTA-2010-TT342)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Dextran-FITC (Cat#: NTA-2011-ZP110)
- AAV2/9-hEF1a-fDIO-eNpHR 3.0-mCherry-WPRE-pA (Cat#: NTA-2012-ZP78)
- pAAV-syn-FLEX-jGCaMP8s-WPRE (Cat#: NTA-2106-P066)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)