Viral Tracer Tools
Non-viral conventional tracers are effective tools for visualizing a large number of neural connections. The only specified parameter is the position of the cell body or axon end. They usually come in a form that is easy to inject and can be tested in any target animal because they do not require specific genetically modified strains or genetic methods. However, the use of non-viral conventional tracers is mainly limited to mapping global connections. Most conventional tracers do not have sufficient resolution to reveal connectivity at the level of molecularly defined cell types. They also did not reveal whether axons that terminate in specific locations are in contact with specific cell types or synapses connected to other cells. Conventional tracers can remain outside the cells at the injection site, and they usually mark the injection site or all cell bodies projected at the injection site.
Instead, genetic strategies can be used to target viruses to specific cell types, for example, through specific expression of viral receptors or through expression of recombinase proteins in specific cells to direct productive infection or payload delivery to these cells. In some cases, the virus can be modified to express a small molecule tracer in the target cell type of interest.
Creative Biolabs offers a variety of viral vectors to replace chemical tracers with targeted viral genetics methods.
Table 1: Properties of
Commonly Used Transneuronal/Trans-synaptic Viral Tracers.
Please don’t hesitate to contact us for more details.
For Research Use Only. Not For Clinical Use.
Premade Viruses
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VSV-eGFP [CAT#: NTA-2011-ZP20]
- Tracer Type:
- Anterograde tracing virus
- Applications:
- Neural Tracing
AAV-pEF1a-FRT-EBFP-UTAN -WPRE-hGH polyA [CAT#: NRZP-0822-ZP249]
- Tracer Type:
- Fluorescent labeling
- Applications:
- Multi-signature neuronal labeling; IBIST
AAV-pEF1a-TA(C)-WPRE-hGH polyA [CAT#: NRZP-0822-ZP248]
- Tracer Type:
- Fluorescent labeling
- Applications:
- Multi-signature neuronal labeling; IBIST
AAV-pEF1a-EBFP-TA(n)-WPRE-HGH polyA [CAT#: NRZP-0822-ZP247]
- Tracer Type:
- Fluorescent labeling
- Applications:
- Multi-signature neuronal labeling; IBIST
BrainBow™ rAAV-EF1a-BbChT-WPRE-hGH polyA [CAT#: NRZP-0822-ZP212]
Custom Vector Development Service
- Tracer Type:
- Fluorescent labeling
BrainBow™ rAAV-EF1a-BbTagBY-WPRE-hGH polyA [CAT#: NRZP-0822-ZP211]
Custom Vector Development Service
- Tracer Type:
- Fluorescent labeling
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Neurotransmitter Sensor
rAAV-hSyn-cyto-iATPSnFR1.0 [CAT#: NRZP-0722-ZP734]
Fluorescent probe
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- ATP Sensor
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Neurotransmitter Sensor
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Neurotransmitter Sensor
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Acetylcholine Sensor
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Neurotransmitter Sensor
rAAV-hSyn-rACh1.8 [CAT#: NRZP-0722-ZP710]
Fluorescent probe
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Acetylcholine Sensor
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Oxytocin Sensor
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Oxytocin Sensor
- Tracer Type:
- Neurotransmitter Sensor
- Applications:
- Neurotransmitter Sensor
- Tracer Type:
- Neurotransmitter Sensor
- Applications:
- Neurotransmitter Sensor
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Adenosine Sensor
rAAV-hSyn-rACh1.7 [CAT#: NRZP-0722-ZP663]
Fluorescent probe
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Acetylcholine Sensor
rAAV-hSyn-rACh1.4 [CAT#: NRZP-0722-ZP661]
Fluorescent probe
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Acetylcholine Sensor
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Acetylcholine Sensor
rAAV-hSyn-HaloNE0.9 [CAT#: NRZP-0722-ZP656]
Fluorescent probe
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Norepinephrine Sensor
rAAV-hSyn-rNE1.1 [CAT#: NRZP-0722-ZP654]
Fluorescent probe
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Norepinephrine Sensor
rAAV-hSyn-rD1-1.5 [CAT#: NRZP-0722-ZP642]
Fluorescent probe
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Dopamine Sensor
GFP (cpGFP)-based cAMP Indicator (G-Flamp1) [CAT#: NRZP-0722-ZP205]
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- Neurotransmitter Sensor
scAAV-Syn-eGFP [CAT#: NRZP-0622-ZP822]
- Tracer Type:
- Fluorescent labeling
scAAV-CMV-GFP [CAT#: NRZP-0622-ZP820]
- Tracer Type:
- Fluorescent labeling
scAAV-CMV-GAP-EGFP [CAT#: NRZP-0622-ZP819]
- Tracer Type:
- Fluorescent labeling
pShuttle-SYN-eGFP [CAT#: NRZP-0622-ZP814]
- Tracer Type:
- Fluorescent labeling
pShuttle-CMV-cre-eGFP-construct-240 [CAT#: NRZP-0622-ZP813]
- Tracer Type:
- Recombinase
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