Creative Biolabs

Viral Tracers

Viral Tracers

Non-viral conventional tracers are effective tools for visualizing a large number of neural connections. The only specified parameter is the position of the cell body or axon end. They usually come in a form that is easy to inject and can be tested in any target animal because they do not require specific genetically modified strains or genetic methods. However, the use of non-viral conventional tracers is mainly limited to mapping global connections. Most conventional tracers do not have sufficient resolution to reveal connectivity at the level of molecularly defined cell types. They also did not reveal whether axons that terminate in specific locations are in contact with specific cell types or synapses connected to other cells. Conventional tracers can remain outside the cells at the injection site, and they usually mark the injection site or all cell bodies projected at the injection site.

Instead, genetic strategies can be used to target viruses to specific cell types, for example, through specific expression of viral receptors or through expression of recombinase proteins in specific cells to direct productive infection or payload delivery to these cells. In some cases, the virus can be modified to express a small molecule tracer in the target cell type of interest.

Creative Biolabs offers a variety of viral vectors to replace chemical tracers with targeted viral genetics methods.

Properties of Commonly Used Transneuronal/Trans-synaptic Viral Tracers. Table 1: Properties of Commonly Used Transneuronal/Trans-synaptic Viral Tracers.

Popular Neuronal Tracing Tools

Cat Product Name Description
NTA-2011-ZP1 RV-EnVA-△G-dsRed Combined with AAV-TVA and AAV-RVG, Retrograde,Monosynaptic
NTA-2011-ZP2 RV-EnVA-△G-GCaMP6s-dsRed Combined with AAV-TVA and AAV-RVG, Retrograde,Monosynaptic, Calcium signal detection
NTA-2011-ZP3 RV-EnVA-△G-mCherry Combined with AAV-TVA and AAV-RVG, Retrograde,Monosynaptic
NTA-2011-ZP4 RV-EnVA-△G-eGFP-synphRFP Combined with AAV-TVA and AAV-RVG, Retrograde,Monosynaptic
NTA-2011-ZP5 RV-EnVA-△G-ChR2-dsRed Combined with AAV-TVA and AAV-RVG, Retrograde,Monosynaptic
NTA-2011-ZP6 RV-EnVA-△G-pre-mGRASP-dsRed Combined with AAV-TVA and AAV-RVG, Retrograde,Monosynaptic
NTA-2011-ZP7 RV-EnVA-△G-post-mGRASP-dsRed Combined with AAV-TVA and AAV-RVG, Retrograde,Monosynaptic
NTA-2011-ZP8 RV-N2C(G)-△G-eGFP Combined with AAV-RVG, Retrograde,Monosynaptic
NTA-2011-ZP9 RV-N2C(G)-△G-dsRed Combined with AAV-RVG, Retrograde,Monosynaptic
NTA-2011-ZP10 RV-N2C(G)-△G-EGFP-synphRFP Combined with AAV-RVG, Retrograde,Monosynaptic
Cat Product Name Description
NTA-2011-ZP11 PRV-CMV-EGFP Retrograde,multisynaptic
NTA-2011-ZP12 PRV-CMV-RFP Retrograde,multisynaptic
NTA-2011-ZP13 PRV-hUbC-EGFP Retrograde,multisynaptic
NTA-2011-ZP14 PRV-CAG-EGFP Retrograde,multisynaptic
Cat Product Name Description
NTA-2011-ZP15 HSV-EGFP Anterograde,multisynaptic
NTA-2011-ZP16 HSV-tdTomato Anterograde,multisynaptic
NTA-2011-ZP17 HSV-LSL-tdtomato-2a-TK(H356) Cre dependent,Anterograde,multisynaptic
NTA-2011-ZP18 HSV-ΔTK-hUbC-tdTomato Combined with AAV-TK,anterograde monosynaptic
NTA-2011-ZP19 HSV-ΔTK-LSL-tdTomato(H361) Cre dependent,Combined with AAV-TK,anterograde monosynaptic
Cat Product Name Description
NTA-2011-ZP20 VSV-eGFP Anterograde,multisynaptic
NTA-2011-ZP21 VSV-mCherry Anterograde,multisynaptic
NTA-2011-ZP22 VSV-BFP Anterograde,multisynaptic
NTA-2011-ZP23 VSV-EnVA-ΔG-eGFP Combined with AAV-TVA and AAV-VSVG, anterograde monosynaptic
NTA-2011-ZP24 VSV-EnVA-ΔG-mCherry Combined with AAV-TVA and AAV-VSVG, anterograde monosynaptic
NTA-2011-ZP25 VSV-ΔG-eGFP Combined with AAV-VSVG, anterograde monosynaptic
NTA-2011-ZP26 VSV-ΔG-mCherry Combined with AAV-VSVG, anterograde monosynaptic
NTA-2011-ZP27 VSV-ΔG-taueGFP Combined with AAV-VSVG, anterograde monosynaptic
NTA-2011-ZP28 VSV-ΔG-taueGFP-ferritin Combined with AAV-VSVG, anterograde monosynaptic

Please don’t hesitate to contact us for more details.

For Research Use Only. Not For Clinical Use.
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