- NeuroMab™ Anti-Tau Antibody,Clone NR2944P (Cat#: NRP-0422-P1684)
- NeuroMab™ Anti-TREM2 BBB Shuttle Antibody, Clone NR19 (Cat#: NRZP-1022-ZP4114)
- NeuroMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- NeuroMab™ Anti-Tau Antibody,Clone NR2946P (Cat#: NRP-0422-P1686)
- NeuroMab™ Anti-Tau Antibody,Clone NR1808P (Cat#: NRP-0422-P2293)
- NeuroMab™ Anti-ApoC3 BBB Shuttle Antibody,Clone NR1738P (Cat#: NRZP-1022-ZP3503)
- NeuroMab™ Anti-CD20 Antibody,Clone NR3021P (Cat#: NRP-0422-P1230)
- NeuroMab™ Anti-Tau Antibody,Clone NR2218P (Cat#: NRP-0422-P2275)
- NeuroMab™ Anti-GARP Antibody,Clone NR3348P (Cat#: NRP-0422-P1639)
- NeuroMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- Human Glial (Oligodendrocytic) Hybrid Cell Line (MO3.13) (Cat#: NCL-2108P34)
- C57 Brain Cortex Neurons [Mouse] (Cat#: NCC20-9PZ48)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Mouse Retinal Ganglion Cell Line RGC-5 (Cat#: NCL2110P154)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Mouse Hippocampal Neuron Cell HT22 (Cat#: NCL2110P001)
- Human Brain Astroblastoma U-87 MG (Cat#: NCL2110P117)
- Mouse Retinal Ganglion Cells (Cat#: NCL2110P145)
- iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) (Cat#: NCL-2103-P49)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Beta Amyloid (1-40), Aggregation Kit, TTF Assay (Cat#: NRZP-0323-ZP199)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Dextran-CYanine5.5 (Cat#: NTA-2011-ZP118)
- AAV-EF1a-mCherry-flex-dtA (Cat#: NRZP-0622-ZP616)
- pAAV-syn-jGCaMP8s-WPRE (Cat#: NTA-2106-P063)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- AAV2/2Retro-CAG-DIO-EGFP-2A-TetTox-pA [Neural Tracing] (Cat#: NTA-2012-ZP303)
- Dextran-FITC (Cat#: NTA-2011-ZP110)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- pAAV-syn-jGCaMP8f-WPRE (Cat#: NTA-2106-P061)
- pAAV-syn-FLEX-jGCaMP8s-WPRE (Cat#: NTA-2106-P066)
- pAAV-EF1a-DIO-EGFP-WPRE (Cat#: NTA-2012AD-P285)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- ABCA1 Antisense Oligonucleotide (AK311445) (Cat#: NV-2106-P27)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein, cTfRMAb-TNFR (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein, cTfRMAb-IDUA (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein, HIRMab-TNFR (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein, HIRMab-IDUA (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-IDS BBB Shuttle Protein, HIRMab-IDS (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-EPO BBB Shuttle Protein, HIRMab-EPO (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein, cTfRMAb-GDNF (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein, 8D3-IL-1RA (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein, HIRMab-GDNF (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-ASA BBB Shuttle Protein, HIRMab-ASA (Cat#: NRZP-0423-ZP504)
Modulators
Understanding how cells behave allows us to see how they are normally regulated when they are in a normal state. These findings can help us better understand how these mechanisms are altered during the beginning and progression of neurodegenerative diseases and identify new biomarkers and therapeutic targets. Creative Biolabs offers a range of modulators, including compounds (inhibitors and agonists) and aptamers, which are valuable tools for researchers.
Compounds
Small molecule compounds mainly affect how proteins work. Right now, small molecule compounds are mostly used to target enzymes, ion channels, and receptors. The role of small molecule compounds can vary depending on the type of target. Even though small molecule compounds are grouped into categories like enzyme inhibitors, ion channel blockers, and receptor agonists/antagonists based on their target types, these divisions aren't always clear-cut because some targets have multiple functions.
Aptamers
Aptamers are oligonucleotides or peptides that have a high degree of selectivity and affinity when binding to particular target molecules. Their strong affinity and specificity have earned them the moniker "antibody alternatives". Aptamers are naturally found in riboswitches, but they may also be manufactured through repeated in vitro selections and bind to a wide range of molecular targets, including small molecules, proteins, nucleic acids, and cells.
To further advance the treatment of Alzheimer's disease, numerous efforts have been made by researchers to create inhibitors of amyloid aggregation. Aptamers are a prospective inhibitor of Aβ aggregation due to their ease of modification, cost-effectiveness, repeatability, biocompatibility, stability, and Aβ selectivity.
![]() |
Fig.1 N2 and E2 RNA aptamers can inhibit aggregation and fibrillation of Aβ peptides. A) TEM images of Aβ 40 aggregates after incubation for 19 h in the absence of RNA aptamers and in the presence of N2 and E2 RNA aptamers.1 |
Applications
Modulators can help you with:
- Answer questions on the involvement of specific signaling nodes in disease.
- Investigate the mechanism of action of disease drugs by inhibiting the main pathway to observe the activation of alternative pathways.
- Identify protein interactions or kinase substrates by activating or inhibiting individual signaling nodes.
If the product you're looking for isn't listed, please contact us immediately. Our experts can help you find a good alternative that can be used as an inhibitor, agonist, delivery tool, and in many research applications. Kindly reach out to us via phone or email, and we will be happy to help you locate the ideal product for your needs.
Reference
- Takahashi, Tsuyoshi, Kosuke Tada, and Hisakazu Mihara. "RNA aptamers selected against amyloid β-peptide (Aβ) inhibit the aggregation of Aβ." Molecular Biosystems 5.9 (2009): 986-991.
Target
![](static/images/loading3.gif)
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Anxiety
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Pain
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Neuroinflammation
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease
![](static/images/product/product-icon-cell-assay-reagents.png)
- Relevant Diseases:
- Alzheimer's Disease