IonON™ Human Nav1.1 Recombinant Stable Cell Line

[CAT#: NCL-7P111]

Creative Biolabs provides numerous IonON cell models of ion channels to meet your drug discovery needs.

Species:: Human

Applications:: GPCR Screening

Cell Types:: GPCR Cell

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Product Overview

Description

The initiation and repetition of neuronal firing by axonal potential as well as the contraction-stimulation coupling of cardiomyocytes are both regulated by the voltage-gated sodium channel subtype Nav1.1. Antiepileptic medications may target Nav1.1 to cause side effects, while centrally active local anaesthetics may also target Nav1.1 to do the same. It was found in the cell bodies of central neurons and cardiomyocytes.

Cell Types

GPCR Cell

Applications

GPCR Screening

Application Notes

Electrophysiology assay (Conventional and automated patch clamp platforms)

Species

Human

Properties

Size

2 Vials of mycoplasma-free cells, 1 mL per vial aliquots containing 2M to 4M cells/mL in DMSO

Mycoplasma Testing

The cell line has been screened using the Mycoplasma Detection Kit to confirm the absence of Mycoplasma contamination.

Shipping

Dry ice.

Storage

Liquid Nitrogen

Research Use Only

For research use only

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Target Details

Target

Nav1.1

Official Name

SCN1A

Full Name

Nav1.1

Alternative Names

Sodium Voltage-Gated Channel Alpha Subunit 1; Sodium Channel; Voltage-Gated; Type I; Alpha Subunit; Voltage-Gated Sodium Channel Subunit Alpha Nav1.1; Sodium Channel Protein Type I Subunit Alpha; SCN1; NAC1; Sodium Channel; Voltage-Gated; Type I; Alpha Polypeptide; Sodium Channel; Voltage Gated; Type I Alpha Subunit; Sodium Channel Voltage Gated Type 1 Alpha Subunit; Sodium Channel Protein; Brain I Alpha Subunit; Sodium Channel Protein Brain I Subunit Alpha;

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