IonON™ Human Nav1.4 Recombinant Stable Cell Line

[CAT#: NCL-7P114]

Creative Biolabs provides numerous IonON cell models of ion channels to meet your drug discovery needs.

Species:: Human

Applications:: GPCR Screening

Cell Types:: GPCR Cell

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Product Overview

Description

hNav1.4 has a role in the beginning and transmission of muscular action potentials and is mostly expressed in skeletal muscle. In order to treat myotonia, a condition marked by the sluggish relaxation of muscles following voluntary contraction or electrical stimulation, this ion channel is the target of a local anaesthetic. Patients with myotonic muscular dystrophy frequently experience myotonia as a symptom.

Cell Types

GPCR Cell

Applications

GPCR Screening

Application Notes

Electrophysiology assay (Conventional and automated patch clamp platforms)

Species

Human

Properties

Size

2 Vials of mycoplasma-free cells, 1 mL per vial aliquots containing 2M to 4M cells/mL in DMSO

Mycoplasma Testing

The cell line has been screened using the Mycoplasma Detection Kit to confirm the absence of Mycoplasma contamination.

Shipping

Dry ice.

Storage

Liquid Nitrogen

Research Use Only

For research use only

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Target Details

Target

Nav1.4

Official Name

SCN4A

Full Name

Nav1.4

Alternative Names

Sodium Voltage-Gated Channel Alpha Subunit 4; Sodium Channel; Voltage-Gated; Type IV; Alpha Subunit; Sodium Channel Protein Skeletal Muscle Subunit Alpha; Voltage-Gated Sodium Channel Subunit Alpha Nav1.4; Sodium Channel Protein Type IV Subunit Alpha; SkM1; Skeletal Muscle Voltage-Dependent Sodium Channel Type IV Alpha Subunit; Sodium Channel; Voltage Gated; Type IV Alpha Subunit; Skeletal Muscle Sodium Channel Alpha Subunit; Sodium Channel Protein Type 4 Subunit Alpha;

Publications