NeuroMab™ Anti-AQP4 BBB Shuttle Antibody, Clone rAb-58
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; In Vitro; Block; In Vivo; ADCC; CDC
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 depicts differential binding of purified monoclonal NMO-IgG to M1 and M23 AQP4.
Representative fluorescence micrographs of rAb-53 and rAb-58 (green) binding as a function of concentration, and a reference AQP4 antibody (red).
Figure 2 depicts differential binding of purified monoclonal NMO-IgG to M1 versus M23 AQP4.
Binding curves of rAb-53 (left), rAb-58 (middle) and rAb-186 (right) to M1 vs. M23 AQP4 (mean ± SE, n=5). The curve representation fits the single-point binding model.
Figure 3 depicts the mechanism for increasing the binding affinity of NMO-IgG to array-assembled AQP4.
Prediction of bivalent versus monovalent binding mechanisms. AQP4 monomers (cylinders) are shown to assemble into tetramers (M1) or OAPs (M23). NMO-IgG (green) binds monovalently or bivalently to the (unknown) extracellular domain on AQP4.
Figure 4 depicts the mechanism for increasing the binding affinity of NMO-IgG to array-assembled AQP4.
Relative M1-M23 binding of whole IgG or purified Fab fragments of mouse anti-Myc (left), rAb-53 (middle) and rAb-58 (right) at fixed concentrations (mean ± SE, n=5).
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