Product
NeuroMab™ Anti-Glycine receptor Alpha3 BBB Shuttle Antibody, Clone N424/45
[CAT#: NRZP-0423-ZP154]
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Glycine Receptor Alpha 3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 342-431 (cytoplasmic loop) of human GlyRAlpha3L (also known as Glycine receptor subunit alpha-3 and GLRA3, accession number O75311)
Mouse: 95% identity (86/90 amino acids identical)
Rat: 93% identity (84/90 amino acids identical)
>80% identity with GlyRAlpha3K (amino acids 358-372 or TEAFALEKFYRFSDM is L-specific)
~50% identity with GlyRAlpha1 and GlyRAlpha2
Mouse: 95% identity (86/90 amino acids identical)
Rat: 93% identity (84/90 amino acids identical)
>80% identity with GlyRAlpha3K (amino acids 358-372 or TEAFALEKFYRFSDM is L-specific)
~50% identity with GlyRAlpha1 and GlyRAlpha2
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N424/45
Applications
WB; IHC; ICC
Application Notes
Cross-reacts with GlyRAlpha3K
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
Glycine Receptor Alpha 3
Official Name
GLRA3
Full Name
Glycine receptor Alpha3
Alternative Names
GLRA3; glycine receptor alpha 3
Uniprot ID
O75311
Product Pictures
IB
Fig. 1 Immunoblot against extracts of COS cells transiently transfected with untagged GlyRAlpha3L, GlyRAlpha3K or Kv2.1 plasmid probed with N424/45 (left) or K89/34 (right) TC supe.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
