Product
NeuroMab™ Anti-Kir2.4 potassium channel BBB Shuttle Antibody, Clone N465/11
[CAT#: NRZP-0423-ZP195]
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNJ14 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 360-434 (cytoplasmic C-terminus) of mouse Kir2.4 (also known as ATPsensitive inward rectifier potassium channel 14, Potassium channel, inwardly rectifying subfamily J member 14, Kcnj14 and Irk4, accession number Q8JZN3)
Rat: 97% identity (73/75 amino acids identical)
Human: 83% identity (62/75 amino acids identical)
<50% identity with Kir2.1/KCNJ2 and other Kir2 potassium channel subunits
Rat: 97% identity (73/75 amino acids identical)
Human: 83% identity (62/75 amino acids identical)
<50% identity with Kir2.1/KCNJ2 and other Kir2 potassium channel subunits
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Mouse; Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N465/11
Applications
WB; IHC; ICC
Research Areas
K+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
KCNJ14
Official Name
KCNJ14
Full Name
Kir2.4 K+ channel
Alternative Names
KCNJ14; IRK4; KIR2.4
Uniprot ID
Q8JZN3
Product Pictures
IHC
Fig. 1 Adult rat brainstem immunohistochemistry of motor trigeminal nucleus.
IHC
Fig. 2 Adult rat brainstem immunohistochemistry of facial motor nucleus.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
