NeuroMab™ Anti-Kir6.2 potassium channel BBB Shuttle Antibody, Clone N363/71

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNJ11 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 345-390 (TARQLDEDRSLLDALTLASSRGPLRKRSVAVAKAKPKFSISP DSLS, cytoplasmic C-terminus) of rat Kir6.2 (also known as ATP-sensitive inward rectifier potassium channel 11, Potassium channel inwardly rectifying subfamily J member 11, IKATP, Kcnj11 and BIR, accession number P70673)
Mouse: 100% identity (46/46 amino acids identical)
Human: 89% identity (41/46 amino acids identical)
<50% identity with Kir6.1

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N363/71

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Kir6.1

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNJ11

Official Name

KCNJ11

Full Name

Kir6.2 K+ channel

Alternative Names

KCNJ11; BIR; HHF2; IKATP; KIR6.2; MODY13; PHHI; TNDM3; potassium voltage-gated channel subfamily J member 11; potassium inwardly rectifying channel subfamily J member 11; PNDM2

Uniprot ID

P70673

Product Pictures

Fig. 1 Immunoblot against extracts of COS cells transiently transfected with Myc-tagged Kir6.1, HA-tagged Kir6.2 or untagged Kv2.1 plasmid probed with N363/71 (left) or N52A/42 (right) TC supe.

Publications