Product
NeuroMab™ Anti-Kv1.2 potassium channel subunit BBB Shuttle Antibody, Clone K14/16
[CAT#: NRZP-0423-ZP203]
- Species Reactivity:
- Human; Rat; Mouse
- Applications:
- WB; IHC; IP; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNA2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 428-499 (QYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSN EDFREENLKTANCTLANTNYVNITKMLTDV, cytoplasmic C-terminus) of human Kv1.2 (also known as Potassium voltage-gated channel subfamily A member 2, Voltage-gated K(+) channel HuKIV or HBK5, Kcna2, NGK1, RAK, RBK2, RCK5 and MK2, accession number P16389), epitope mapped to within underlined sequence (amino acids 463-480)
Mouse: 100% identity (72/72 amino acids identical)
Rat: 100% identity (72/72 amino acids identical)
Some identity with Kv1.1, Kv1.3 and Kv1.4
Mouse: 100% identity (72/72 amino acids identical)
Rat: 100% identity (72/72 amino acids identical)
Some identity with Kv1.1, Kv1.3 and Kv1.4
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Rat; Mouse
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
K14/16
Applications
WB; IHC; IP; ICC
Application Notes
Does not cross-react with other Kv1 channels
Research Areas
K+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
KCNA2
Official Name
KCNA2
Full Name
Kv1.2 K+ channel
Alternative Names
KCNA2; Potassium voltage-gated channel; shaker-related subfamily; member 2
Uniprot ID
P16389
Product Pictures
IHC
Fig. 1 Adult rat hippocampus immunohistochemistry.
IB
Fig. 2 Immunoblot on membranes from whole rat (RBM) and mouse (MBM) brain and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].
IF
Fig. 3 Immunofluorescence on brains from wild-type (WT) and Kv1.2 knockout (KO) mice.
IB
Fig. 4 Immunoblots on RBM and brain membranes from frog (FBM) and zebrafish (ZBM) [left] and from WT and Kv1.2 knockout (Kv1.2-/-) mice [right].
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
