NeuroMab™ Anti-Kv3.3 potassium channel BBB Shuttle Antibody, Clone N375/67

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNC3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 628-728 (cytoplasmic C-terminus) of mouse Kv3.3b (also known as Potassium voltage-gated channel subfamily C member 3, KSHIIID and Kcnc3, accession number Q63959)
Human: 96% identity (94/97 amino acids identical)
Rat: 90% identity (96/106 amino acids identical)
100% identity with Kv3.3a for first 30 amino acids (AGGLGIMGLPPLPAPGEPCPLEEVIETNRA)
<40% identity with Kv3.4 or Kv3.2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N375/67

Applications

WB; IHC; ICC

Application Notes

Cross-reacts with Kv3.3a;Does not cross-react with Kv3.4 or Kv3.2

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNC3

Official Name

KCNC3

Full Name

Kv3.3 K+ channel

Alternative Names

Potassium Voltage-Gated Channel Subfamily C Member 3; Potassium Channel; Voltage Gated Shaw Related Subfamily C; Member 3; Potassium Voltage-Gated Channel; Shaw-Related Subfamily; Member 3; Voltage-Gated Potassium Channel Subunit Kv3.3; KSHIIID; Shaw-Related Voltage-Gated Potassium Channel Protein 3;

Uniprot ID

Q63959

Product Pictures

Fig. 1 Immunoblot against adult rat brain membrane (RBM) fractions and extracts of COS cells transiently transfected with untagged Kv3.3a, Kv3.3b or Kv2.1 plasmid probed with N375/67 (left) or N52A/42 (right) TC supe.