NeuroMab™ Anti-MAP3K12 BBB Shuttle Antibody, Clone N377/20

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-MAP3K12 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 727-888 (C-terminus) of mouse MAP3K12 (also known as Mitogenactivated protein kinase kinase kinase 12, Dual leucine zipper bearing kinase, Leucine-zipper protein kinase, MAPK-upstream kinase, Mixed lineage kinase, DLK, ZPK and MUK, accession number Q60700)
Rat: 97% identity (158/162 amino acids identical)
Human: 86% identity (143/166 amino acids identical)
<40% identity with MAP3K13

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N377/20

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with MAP3K13

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

MAP3K12

Official Name

MAP3K12

Full Name

MAP3K12

Alternative Names

MAP3K12; DLK; MEKK12; MUK; ZPK; ZPKP1; mitogen-activated protein kinase kinase kinase 12

Uniprot ID

Q60700

Product Pictures

Fig. 1 Immunoblot against extracts of COS cells transiently transfected with GFP-tagged MAP3K12, MAP3K13 or untagged Kv2.1 plasmid; adult rat brain low-speed pellet (RBLSP) or membrane (RBM) fractions; and membranes from MAP3K12 wild-type (WT) and genetrap knockout (KO) mice probed with N377/20 TC supe.

Fig. 2 Immunoblot against extracts of COS cells transiently transfected with GFP-tagged MAP3K12, MAP3K13 or untagged Kv2.1 plasmid; adult rat brain low-speed pellet (RBLSP) or membrane (RBM) fractions; and membranes from MAP3K12 wild-type (WT) and genetrap knockout (KO) mice probed with N52A/42 TC supe.