NeuroMab™ Anti-NGL-1 (Netrin-G1 ligand) BBB Shuttle Antibody, Clone N49A/21

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-LRRC4C BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 551-640 (cytoplasmic C-terminus) of human NGL-1 (also known as Netrin-G1 ligand, Leucine-rich repeat-containing 4C, LRRC4C, KIAA1580 and UNQ292/PRO331, accession number Q9HCJ2)
Mouse: 100% identity (90/90 amino acids identical)
Rat: 100% identity (90/90 amino acids identical)
<40% identity with NGL-2 and NGL-3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N49A/21

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with NGL-2 or NGL-3

Research Areas

CAMs

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

LRRC4C

Official Name

LRRC4C

Full Name

NGL-1/LRRC4C

Alternative Names

NGL-1; NGL1

Uniprot ID

Q9HCJ2

Product Pictures

Fig. 1 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with Myc-tagged NGL-1, NGL-2, NGL-3 or untagged Kv2.1 plasmid and probed with N49A/21 (left and middle) or K89/34 (right) TC supe.

Publications