NeuroMab™ Anti-NGL-3 (Netrin-G3 ligand) BBB Shuttle Antibody, Clone N51/6

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-LRRC4B BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 598-709 (cytoplasmic C-terminus) of rat NGL-3 (also known as NetrinG3 ligand, Leucine-rich repeat-containing protein 4B, Lrrc4b and Lrig4, accession number P0CC10)
Mouse: 100% identity (112/112 amino acids identical)
Human: 94% identity (105/112 amino acids identical)
<40% identity with NGL-1 and NGL-2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N51/6

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with NGL-1 or NGL-2

Research Areas

CAMs

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

LRRC4B

Official Name

LRRC4B

Full Name

NGL-3/LRRC4B

Alternative Names

NGL-2; NGL2

Uniprot ID

P0CC10

Product Pictures

Fig. 1 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with Myc-tagged NGL-1, NGL-2 NGL-3 or untagged Kv2.1 plasmid and probed with N51/6 TC supe.

Fig. 2 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with Myc-tagged NGL-1, NGL-2 NGL-3 or untagged Kv2.1 plasmid and probed with K89/41 TC supe.

Publications