NeuroMab™ Anti-Notch1 BBB Shuttle Antibody, Clone 351
- Host Species:
- Rat
- Species Reactivity:
- Human; Mouse
- Applications:
- ELISA; WB; IHC; Inhib; In Vitro
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 shows the neutralizing activity of humanized 438 VH1.1/VL1.8 and rat 438 antibodies against Notch1-dependent signaling in human Notch1 reporter cells.
Figure 2 shows the neutralizing activity of humanized 438 VH1.1/VL1.8 and rat 438 antibodies on Notch1-dependent signaling in mouse Notch1 reporter cells.
Figure 3 shows the neutralizing activity of humanized 351 mutant and rat 351-mIgG1 in a human Notch1-dependent signaling reporter assay.
Figure 4 shows the neutralizing activity of humanized 351 mutants and rat 351-mIgG1 in a mouse Notch1-dependent signaling reporter assay.
Figure 5 Treatment of HBP-ALL cells with increasing concentrations of rat 438-mIgG1 and humanized 438VH1.1/VL1.8 significantly inhibited constitutive Notch1 activation.
Figure 6 shows the histochemical identification of secretory goblet cells using Alcian blue staining on ileal sections of mouse intestine obtained from a Calu-6 efficacy study.
Figure 7 shows representative Figures of intestinal crypts stained with Ki67, where Ki67 staining was reduced in animals treated with rat 351-mIgG1 at the bottom of the crypts
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