NeuroMab™ Anti-SK2 potassium channel BBB Shuttle Antibody, Clone K78/29

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNN2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 546-562 (ENYDKHVTYNAERSRSS, cytoplasmic C-terminus) of rat SK2 (also known as Small conductance calcium-activated potassium channel protein 2, SKCa2, KCa2.2 and Kcnn2, accession number P70604)
Mouse: 94% identity (16/17 amino acids identical)
Human: 94% identity (16/17 amino acids identical)
<50% identity with SK3 and other SK channels

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K78/29

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with other SK channels

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNN2

Official Name

KCNN2

Full Name

SK2 K+ channel

Alternative Names

KCNN2; KCa2.2; SK2; SKCA2; SKCa 2; hSK2; potassium calcium-activated channel subfamily N member 2

Uniprot ID

P70604

Product Pictures

Fig. 1 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with GFP-tagged SK1, SK3 or SK4 or untagged SK2 or Kv2.1 plasmid and probed with K78/29 (left) and N86/8 (right) TC supe.