Product
NeuroMab™ Anti-SUR1 and SUR2B BBB Shuttle Antibody, Clone N323A/31
[CAT#: NRZP-0423-ZP400]
- Species Reactivity:
- Rat; Mouse
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SUR2B BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1503-1545 (VHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFVRADM, cytoplasmic C-terminus) of rat SUR2B (also known as Sulfonylurea receptor 2B, ATP-binding cassette transporter subfamily C member 9B and Abcc9B, accession number Q63563-2)
Mouse: 100% identity (43/43 amino acids identical)
Human: 97% identity (42/43 amino acids identical)
>75% identity with SUR1
Mouse: 100% identity (43/43 amino acids identical)
Human: 97% identity (42/43 amino acids identical)
>75% identity with SUR1
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N323A/31
Applications
WB; IHC; ICC
Application Notes
Cross-reacts with SUR1
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
SUR2B
Official Name
SUR2B
Full Name
SUR1 and SUR2B
Alternative Names
SUR1; SUR2B
Product Pictures
IB
Fig. 1 Immunoblot versus extracts of heart tissue from WT and SUR2 KO mice probed with N323A/31 TC supe.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
