NeuroMab™ Anti-Reelin Monoclonal Antibody, Clone NR1001P (CBP17816)

[CAT#: NRZP-0223-ZP129]

Host Species:: Rabbit

Species Reactivity:: Human; Rat

Applications:: WB

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Lot Number

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Product Overview

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Rabbit

Clone Number

CBP17816

Applications

Product Properties

Formulation

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Shipping

Gel Packs

Storage

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Target

RELN

Alternative Names

Reelin (RELN) [5] is a secreted large extracellular matrix glycoprotein that can help regulate neuronal migration and localization in the developing brain by controlling cell-cell interactions. In addition to playing an important role in early development; Reelin also continues to play a role in the adult brain. [6] It regulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. [7] [8] It also stimulates the development of dendrites [9] and dendritic spines [10] and regulates the continued migration of neuroblasts produced in adult neurogenesis sites (such as the subventricular and subgranular regions). It is found not only in the brain; but also in the liver; thyroid; adrenal glands; fallopian tubes; and breasts; and is also low in a range of anatomical regions. [11]