NeuroMab™ Rat Anti-Human PROX1 Monoclonal Antibody (CBP2458)

Product Overview

Description

Prospero homeobox protein 1 (PROX1) is a homeobox transcription factor responsible for progenitor cell differentiation and the development of several organs, such as the central nervous system, lymphatics, pancreas, heart, lens, skeletal muscle, and liver. Prox1-deficient mice lack lymphatic systems and die at day 14.5 of embryogenesis due to multiple developmental defects. In addition to its role in physiological development, PROX1 is involved in carcinogenesis and can act either as a tumor suppressor or as an oncogene depending on the tissue and its expression level. Prox1 is also implicated in the regulation of metabolism in the liver by regulating activities of nuclear receptors including hepatocyte nuclear factor 4a (HNF4a) and liver receptor homolog-1 (LRH-1).

Immunogen

Human Prox1 recombinant protein (2-259 a.a.) expressed in E. coli.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a, κ

Clone Number

CBP2458

Applications

ICC

Application Notes

ICC (1:100-1:1000)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1799

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

Batch Dependent

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Handling Advice

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

PROX1

Official Name

PROX1

Full Name

Prospero homeobox protein 1

Alternative Names

PROX1; prospero homeobox 1

Gene ID

5629(Human); 19130(Mouse); 305066(Rat)

Uniprot ID

Q92786(Human); P48437(Mouse)

References

1. Kivelä R, et al. 2016. Nat. Commun. 7:13124.
2. Stergiopoulos A, et al. 2015. Front Cell Neurosci. 8:454.
3. Ragusa S, et al. 2014. Cell Rep. 8:1957.
4. Elsir T, et al. 2012. Cancer Metastasis Rev. 31:793.
5. Karalay O, et al. 2011. Proc. Natl. Acad. Sci. USA. 108:5807.
6. Johnson NC, et al. 2008. Genes Dev. 22:3282.

Publications