NeuroMab™ Mouse Anti-Human TPP1 Monoclonal Antibody (CBP2489)

Product Overview

Description

TPP1 is a member of the sedolisin family of serine proteases. The proenzyme is activated in the lysosome by auto-proteolysis where it cleaves tripeptides from the N-termini of substrates. Mutations of TPP1 are associated with late-infantile neuronal ceroid lipofuscinosis and Spinocerebellar Ataxia, Autosomal Recessive 7.

Immunogen

Recombinant mature human TPP1 expressed in E. coli.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2489

Applications

WB; IHC-P

Application Notes

WB (1.0-5.0 µg/mL); IHC-P (1.0-5.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1821

Product Properties

Form

Liquid

Formulation

This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.PreparationThe antibody was purified by affinity chromatography and conjugat

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Handling Advice

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

TPP1

Official Name

TPP1

Full Name

Tripeptidyl Peptidase 1

Alternative Names

Tripeptidyl Peptidase 1; Cell Growth-Inhibiting Gene 1 Protein; Tripeptidyl Aminopeptidase; Tripeptidyl Peptidase I; EC 3.4.14.9; TPP-1; CLN2; LPIC; Ceroid-Lipofuscinosis; Neuronal 2; Late Infantile (Jansky-Bielschowsky Disease); Spinocerebellar Ataxia; Autosomal Recessive 7;

Gene ID

1200(Human); 12751(Mouse); 83534(Rat)

Uniprot ID

O14773(Human); O89023(Mouse); Q9EQV6(Rat)

References

1. Getty AL, Pearce DA. 2011. Cell Mol. Life Sci. 68:453-74.
2. Cárcel-Trullols J, et al. 2015. Biochim. Biophys. Acta. 2242-55.
3. Kyttälä A, et al. 2006. Biochim Biophys Acta. 920-33.

Publications