Human iPSC-derived Neurons Recording Assay

iPSC-derived neurons are increasingly used for drug discovery. Drug candidates can be evaluated in iPSC neurons derived from healthy as well as diseased human subjects. Genetic and biochemical manipulation of stem cells has empowered world scientists to theoretically generate any kind of cells, including any kind of neuron. As a world-renowned CRO expert in patch clamp electrophysiology, Creative Biolabs provides fast and reliable patch clamp recording data on human iPSC-derived neurons to accelerate your pre-clinical neurodegenerative diseases drug discovery programs until the IND claim.

Fig.1 iPSC-derived neurons for electrophysiology recordings. (Girardin, et al., 2022)

Description

Investigating your compound's activity on human neurons is a key step to help validate early the translation of rodent data to a human. Our scientists have extensive experience in culturing human iPSC-derived neurons and are able to physiologically characterize your cells or investigate your compound effects on single neurons.

Typically, we can perform electrophysiological recordings from:

• Healthy & neurodegenerative diseases patient-derived iPSCs
• Glutamatergic neurons
• Dopaminergic neurons
• GABAergic neurons
• Motor neurons
• Sensory neurons

Available Protocols for Patch Clamp

Available Protocols for Muti-Electrode Array (MEA) & HD MEA

Sample Data

Contact us for more information.

Reference

1. Girardin, S.; et al. Topologically controlled circuits of human iPSC-derived neurons for electrophysiology recordings. Lab on a Chip. 2022, 22(7): 1386-1403.