Human Microglia Cell Line, Immortalized

Excellent

The cells showed robust proliferation and maintained typical microglial morphology

Impressed with the HMC3 cell line's ability to mimic primary microglia behavior, essential for our investigations into Alzheimer's disease pathogenesis. The cells exhibited significant phagocytic activity and cytokine secretion patterns akin to activated microglia.

Excellent

Excellent compatibility

The HMC3 cells demonstrated excellent compatibility with our imaging assays, allowing detailed visualization of microglial dynamics in response to various stimuli. Their consistent performance enabled high-content screening of anti-inflammatory compounds.

Excellent

Stable phenotype

We chose the HMC3 cell line for its well-documented transcriptomic profile resembling primary microglia. This authenticity facilitated accurate interpretation of RNA-seq data, aiding our studies on gene expression changes in neuroinflammatory conditions.

Excellent

Great authenticity and suitability

The HMC3 cells' expression of key microglial markers validated their authenticity and suitability for immunocytochemical assays. Their consistent antigen expression patterns facilitated accurate characterization of microglial activation states.

Excellent

Leveraged cell line's phagocytic capacity

We leveraged the HMC3 cell line's phagocytic capacity to study its implications in neurodegenerative clearance mechanisms. The cells' efficient engulfment of fluorescent particles enabled quantitative analysis of phagocytic activity.