Product
NeuroMab™ Anti-AQP4 BBB Shuttle Antibody, Clone rAb-186
[CAT#: NRZP-1022-ZP3671]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; In Vitro; Block; In Vivo; ADCC; CDC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Clone Number
rAb-186
Applications
WB; In Vitro; Block; In Vivo; ADCC; CDC
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
AQP4
Official Name
AQP4
Full Name
Aquaporin 4
Alternative Names
AQP4; Aquaporin 4
Product Pictures
FuncS
Figure 1 depicts the differential binding of purified monoclonal NMO-IgG to M1 and M23 AQP4.
Binding curves of rAb-53 (left), rAb-58 (middle) and rAb-186 (right) to M1 vs. M23 AQP4 (mean ± SE, n=5). The curve representation fits the single-point binding model.
FuncS
Figure 2 depicts that mutated, non-pathogenic rAb-53 (aquaporumab) blocks binding of pathogenic NMO-IgG to AQP4.
An irrelevant monoclonal NMO antibody and human NMO serum blocked the binding of Cy3-labeled rAb-53 to AQP4.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
