NeuroMab™ Anti-CD40 BBB Shuttle Antibody, Clone APX005
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- In Vitro; Cyt; ADCC; Inhib; In Vivo; ELISA
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 is a graph showing the results of an ELISA assay demonstrating that APX005 selectively binds CD40 but not other TNFR family members.
Figure 2 is a graph showing the results of an ELISA assay demonstrating that APX005 blocks the binding of CD40L to CD40.
Figure 3 is a graph showing that APX005 is not internalized after binding to CD40 positive cells.
Figure 4 is a graph showing APX005-mediated ADCC of CD40 positive Ramos (Figure 8A) and Daudi (Figure 8B) tumor cells.
Figure 5 is a graph showing the in vitro inhibition of Ramos tumor cell proliferation by APX005 Group A without Fc cross-linking; Group B with Fc cross-linking.
Figure 6 is a bar graph showing that APX005 induces DC activation.
Figure 7 shows that APX005 binds human and monkey CD40 but not mouse CD40.
Figure 8 is a graph showing that APX005 inhibits tumor growth in the Ramos model. Figure 12B is a bar graph showing serum human IgG levels in mice on day 34, two days after the last dose.
Figure 9 is a graph showing inhibition of rituximab pretreatment and resistant tumors in a mouse model.
Figure 10 is a graph showing that APX005 inhibits tumor growth in the Raji mouse model.
Figure 11 is a graph showing the potent anti-tumor activity of APX005 against human multiple myeloma in the IM-9 xenograft model.
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