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NeuroMab™ Anti-HMGB1 BBB Shuttle Antibody,Clone NR1305P
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse
- Applications:
- ELISA; In Vitro; In Vivo; IHC
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 is a photograph showing the results of analysis of dendritic spines of an independent 5×FAD mouse group, etc., using a two-photon microscope.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-1.png)
Figure 2 is a graph showing the results of analysis of dendritic spines and the like in an independent AD model mouse group using a two-photon microscope.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-2.png)
Figure 3 is a photo of the DNA damage (γH2AX) detection results in the cerebral cortex of 6-month-old 5×FAD mice injected with anti-HMGB1 antibody subcutaneously at 1 to 6 months or using Western blot at 3 to 6 months of age.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-3.png)
Figure 4 is a graph showing the concentration of biotin-labeled IgG in plasma of mice and the like on day 3 after subcutaneous injection of IgG into mice.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-4.png)
Figure 5 is a photograph showing the results of analysis of the in vitro effects of HMGB1 and anti-HMGB1 antibodies on amyloid β (AM polymerization, Aβ oligomerization, Aβ-HMGB1 heteromer formation, and HMGB1 oligomerization), using anti-Aβ antibody Western blot antibodies.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-5.png)
Figure 6 is a photograph showing the results of observation of aggregated samples in vitro with an electron microscope.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-6.png)
Figure 7 is a graph showing the results of quantitative analysis of the number of microglial cells in the field of view (n=10, cerebral cortex) of the fluorescence micrographs.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-7.png)
Figure 8 is a graph showing the results of quantitative analysis of the number of plaques formed by microglia in the field of view (n=30, cerebral cortex) of the fluorescence micrographs.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-8.png)
Figure 9 is a graph showing the results of quantitative analysis of phagocytosis of fluorescent Aβ by primary cultured rat microglia.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-9.png)
Figure 10 is a photograph showing the results of in vitro polymerization analysis of HMGB1 in the absence of Aβ using an anti-HMGB1 antibody (rabbit-derived polyclonal antibody) by Western blotting.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-10.png)
Figure 11 is a photograph showing the results of in vitro polymerization of HMGB1 analyzed by Western blotting using an anti-HMGB1 antibody (rabbit-derived polyclonal antibody).
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-11.png)
Figure 12 is a photograph showing the results of further analyzing the effect of HMGB1 and the anti-HMGB1 antibody on Aβ oligomerization by Western blotting using an anti-Aβ antibody (6E10).
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-12.png)
Figure 13 is a photograph showing the results of immunohistochemical analysis in brain tissue using avidin-HRP and DAB chromogenicity to detect biotin-labeled IgG in mice subcutaneously injected with IgG.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP4009-13.png)
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