Neurological Disease Related Virus

Creative Biolabs offers Adeno-associated virus (AAVs) tools for neurodegenerative disease modeling. They can target hSNCA, Tau, APP, and TDP43, among other targets, which can help accelerate your study and make them an excellent candidate for developing neurodegenerative disease models.

Parkinson's disease (PD) Modeling Tools

The major pathological changes in PD include the degeneration and death of dopaminergic neurons in the substantia nigra and the misfolding and accumulation of Lewy bodies composed of α-synuclein. There are currently two mainstream PD models, one based on neurotoxins that damage dopaminergic neurons and the other based on α-synuclein.

Alzheimer's disease (AD) modeling tools

AD brains exhibit extracellular plaques of amyloid β (Aβ) and intraneuronal neurofibrillary tangles (NFTs) made up of hyperphosphorylated Tau protein. Our scientific team has developed AAV-mediated gene expression through various delivery routes to construct AD models.

Amyotrophic lateral sclerosis (ALS) modeling tools

ALS is an adult-onset neurodegenerative disease, also known as Lou Gehrig's disease/motor neuron disease (MND), characterized by axonal degeneration leading to the destruction of nerve endings, resulting in the progressive loss of motor neurons. Our ALS modeling tools use AAV vectors to express TDP-43 via temporal vein injection and stereotactic brain injection to simulate some ALS symptoms and pathological features.

Advantages

• AAV vectors can be targeted at specific brain areas.
• AAV tools enable transgenic expression in adult animals, avoiding the effects of compensatory mechanisms during development.
• With AAV tools, you can generate disease models with different doses, different species (rodents, non-human primates), and different gene combinations.
• Models generated with AAV tools exhibited time-dependent neuropathologic changes (neuroinflammation and increased cytoplasmic inclusions).
• To meet different experimental needs, AAV tools offer more options: different AAV serotypes, different broad-spectrum or specific promoters, etc.

Creative Biolabs provides a variety of neurological disease-related viruses that are ready to use. To locate the product you require, please peruse our product list. In accordance with your experimental requirements, you can also freely combine serotypes, promoters, functional genes, and expression techniques. We are pleased to provide you with specialized products. To expedite your study on neurological diseases, please get in touch with us.