Neurological Disease related Virus Products

Creative Biolabs offers Adeno-associated virus (AAVs) tools for neurodegenerative disease modeling. They can target hSNCA, Tau, APP, and TDP43, among other targets, which can help accelerate your study and make them an excellent candidate for developing neurodegenerative disease models.

Parkinson's disease (PD) Modeling Tools

The major pathological changes in PD include the degeneration and death of dopaminergic neurons in the substantia nigra and the misfolding and accumulation of Lewy bodies composed of α-synuclein. There are currently two mainstream PD models, one based on neurotoxins that damage dopaminergic neurons and the other based on α-synuclein.

Cat. No.	Product Name	Functional Gene
NRYF-0624-XY2	AAV2/9-hSyn-SNCA(A53T)-3Flag-WPRE-pA	SNCA(A53T)
NRYF-0624-XY3	AAV2/9-hEF1a-DIO-mCherry-P2A-hSNCA-WPRE-pA	hSNCA
NRYF-0624-XY4	AAV2/9-hSyn-hSNCA-WPRE-pA	hSNCA
NRYF-0624-XY5	AAV2/1-CMV_bGI-hSNCA-WPRE-pA	hSNCA
NRYF-0624-XY6	AAV2/1-CMV_bGI-HA-hSNCA-WPRE-pA	hSNCA

Alzheimer's disease (AD) modeling tools

AD brains exhibit extracellular plaques of amyloid β (Aβ) and intraneuronal neurofibrillary tangles (NFTs) made up of hyperphosphorylated Tau protein. Our scientific team has developed AAV-mediated gene expression through various delivery routes to construct AD models.

Cat. No.	Product Name	Functional Gene
NRYF-0624-XY7	rAAV-SYN-tau(p301L)-WPRE-bGHpA	Tau(p301L)
NRYF-0624-XY8	rAAV-SYN-APPs1-L-WPRE-bGHpA	APPs1-L
NRYF-0624-XY9	rAAV-SYN-PS1-M146L-WPRE-bGHpA	PS1-M146L
NRYF-0624-XY10	-rAAV--SYN-APPs1a-L-A-WPRE-bGHpA	APPs1a-L

Amyotrophic lateral sclerosis (ALS) modeling tools

ALS is an adult-onset neurodegenerative disease, also known as Lou Gehrig's disease/motor neuron disease (MND), characterized by axonal degeneration leading to the destruction of nerve endings, resulting in the progressive loss of motor neurons. Our ALS modeling tools use AAV vectors to express TDP-43 via temporal vein injection and stereotactic brain injection to simulate some ALS symptoms and pathological features.

Cat. No.	Product Name	Functional Gene
NRYF-0624-XY11	rAAV-SYN-TDP-43-WPRE-bGHpA	TDP-43
NRYF-0624-XY12	rAAV-SYN-TDP-43(M337V)-WPRE-bGHpA	TDP-43(M337V)
NRYF-0624-XY13	rAAV-SYN-TDP-25-WPRE-bGHpA	TDP-25
NRYF-0624-XY14	rAAV-SYN-TDP-43∆NLS-WPRE-bGHpA	TDP-43∆NLS

Advantages

AAV vectors can be targeted at specific brain areas.
AAV tools enable transgenic expression in adult animals, avoiding the effects of compensatory mechanisms during development.
With AAV tools, you can generate disease models with different doses, different species (rodents, non-human primates), and different gene combinations.
Models generated with AAV tools exhibited time-dependent neuropathologic changes (neuroinflammation and increased cytoplasmic inclusions).
To meet different experimental needs, AAV tools offer more options: different AAV serotypes, different broad-spectrum or specific promoters, etc.

Creative Biolabs provides a variety of neurological disease-related viruses. In accordance with your experimental requirements, you can also freely combine serotypes, promoters, functional genes, and expression techniques. We are pleased to provide you with specialized products. To expedite your study on neurological diseases, please get in touch with us.

Intellectual Property

Creative Biolabs is a contract manufacturer that produces tailored viruses and vectors according to client specifications. Importantly, this manufacturing service does not grant Creative Biolabs any intellectual property ownership; all designs and associated intellectual property rights remain exclusively with the customer.

Certain vector components may be subject to third-party intellectual property rights. Creative Biolabs offers publicly available sequence information for these components as a convenience for reference only. The customer assumes full responsibility and liability for the use of these components in their custom vectors. By purchasing vectors containing such components, the customer confirms they have secured all necessary intellectual property licenses, including the right to engage Creative Biolabs for manufacturing.

For Research Use Only. Not For Clinical Use.

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