Neurological Disease related Virus Products
Creative Biolabs offers Adeno-associated virus (AAVs) tools for neurodegenerative disease modeling. They can target hSNCA, Tau, APP, and TDP43, among other targets, which can help accelerate your study and make them an excellent candidate for developing neurodegenerative disease models.
Parkinson's disease (PD) Modeling Tools
The major pathological changes in PD include the degeneration and death of dopaminergic neurons in the substantia nigra and the misfolding and accumulation of Lewy bodies composed of α-synuclein. There are currently two mainstream PD models, one based on neurotoxins that damage dopaminergic neurons and the other based on α-synuclein.
Cat. No. | Product Name | Functional Gene |
NRYF-0624-XY2 | AAV2/9-hSyn-SNCA(A53T)-3Flag-WPRE-pA | SNCA(A53T) |
NRYF-0624-XY3 | AAV2/9-hEF1a-DIO-mCherry-P2A-hSNCA-WPRE-pA | hSNCA |
NRYF-0624-XY4 | AAV2/9-hSyn-hSNCA-WPRE-pA | hSNCA |
NRYF-0624-XY5 | AAV2/1-CMV_bGI-hSNCA-WPRE-pA | hSNCA |
NRYF-0624-XY6 | AAV2/1-CMV_bGI-HA-hSNCA-WPRE-pA | hSNCA |
Alzheimer's disease (AD) modeling tools
AD brains exhibit extracellular plaques of amyloid β (Aβ) and intraneuronal neurofibrillary tangles (NFTs) made up of hyperphosphorylated Tau protein. Our scientific team has developed AAV-mediated gene expression through various delivery routes to construct AD models.
Cat. No. | Product Name | Functional Gene |
NRYF-0624-XY7 | rAAV-SYN-tau(p301L)-WPRE-bGHpA | Tau(p301L) |
NRYF-0624-XY8 | rAAV-SYN-APPs1-L-WPRE-bGHpA | APPs1-L |
NRYF-0624-XY9 | rAAV-SYN-PS1-M146L-WPRE-bGHpA | PS1-M146L |
NRYF-0624-XY10 | -rAAV--SYN-APPs1a-L-A-WPRE-bGHpA | APPs1a-L |
Amyotrophic lateral sclerosis (ALS) modeling tools
ALS is an adult-onset neurodegenerative disease, also known as Lou Gehrig's disease/motor neuron disease (MND), characterized by axonal degeneration leading to the destruction of nerve endings, resulting in the progressive loss of motor neurons. Our ALS modeling tools use AAV vectors to express TDP-43 via temporal vein injection and stereotactic brain injection to simulate some ALS symptoms and pathological features.
Cat. No. | Product Name | Functional Gene |
NRYF-0624-XY11 | rAAV-SYN-TDP-43-WPRE-bGHpA | TDP-43 |
NRYF-0624-XY12 | rAAV-SYN-TDP-43(M337V)-WPRE-bGHpA | TDP-43(M337V) |
NRYF-0624-XY13 | rAAV-SYN-TDP-25-WPRE-bGHpA | TDP-25 |
NRYF-0624-XY14 | rAAV-SYN-TDP-43∆NLS-WPRE-bGHpA | TDP-43∆NLS |
Advantages
- AAV vectors can be targeted at specific brain areas.
- AAV tools enable transgenic expression in adult animals, avoiding the effects of compensatory mechanisms during development.
- With AAV tools, you can generate disease models with different doses, different species (rodents, non-human primates), and different gene combinations.
- Models generated with AAV tools exhibited time-dependent neuropathologic changes (neuroinflammation and increased cytoplasmic inclusions).
- To meet different experimental needs, AAV tools offer more options: different AAV serotypes, different broad-spectrum or specific promoters, etc.
Creative Biolabs provides a variety of neurological disease-related viruses. In accordance with your experimental requirements, you can also freely combine serotypes, promoters, functional genes, and expression techniques. We are pleased to provide you with specialized products. To expedite your study on neurological diseases, please get in touch with us.
Intellectual Property
Creative Biolabs is a contract manufacturer that produces tailored viruses and vectors according to client specifications. Importantly, this manufacturing service does not grant Creative Biolabs any intellectual property ownership; all designs and associated intellectual property rights remain exclusively with the customer.
Certain vector components may be subject to third-party intellectual property rights. Creative Biolabs offers publicly available sequence information for these components as a convenience for reference only. The customer assumes full responsibility and liability for the use of these components in their custom vectors. By purchasing vectors containing such components, the customer confirms they have secured all necessary intellectual property licenses, including the right to engage Creative Biolabs for manufacturing.


Neuronal tracing
- Tracer Type:
- Virus Vector/Partical
- Applications:
- Neural Tracing

Specific Promoter
- Tracer Type:
- Neurological Disease Related Virus
- Applications:
- Alzheimer's disease
- iNeuMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- iNeuMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- iNeuMab™ Anti-F-Spondin/SPON1 Antibody, Clone 3F4 (Cat#: NRZP-0822-ZP4740)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- Rat Immortalized Retinal Muller Cell Line rMC-1 (Cat#: NCL-2106-S93)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Human Retinal Epithelial Cell ARPE-19 (Cat#: NCL2110P069)
- iNeu™ Human Schwann Cell (Cat#: NCL-2103-P63)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Rat Schwann Cells RSC96, Immortalized (Cat#: NCL-2108P21)
- Mouse Retinal Ganglion Cells (Cat#: NCL2110P145)
- iNeu™ Human Motor Neurons (Cat#: NCL-2103-P71)
- Rat Muller Cell (Cat#: NCL2110P040)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)