Neurological Disease Related Virus
Creative Biolabs offers Adeno-associated virus (AAVs) tools for neurodegenerative disease modeling. They can target hSNCA, Tau, APP, and TDP43, among other targets, which can help accelerate your study and make them an excellent candidate for developing neurodegenerative disease models.
Parkinson's disease (PD) Modeling Tools
The major pathological changes in PD include the degeneration and death of dopaminergic neurons in the substantia nigra and the misfolding and accumulation of Lewy bodies composed of α-synuclein. There are currently two mainstream PD models, one based on neurotoxins that damage dopaminergic neurons and the other based on α-synuclein.
Cat. No. | Product Name | Functional Gene |
NRYF-0624-XY2 | AAV2/9-hSyn-SNCA(A53T)-3Flag-WPRE-pA | SNCA(A53T) |
NRYF-0624-XY3 | AAV2/9-hEF1a-DIO-mCherry-P2A-hSNCA-WPRE-pA | hSNCA |
NRYF-0624-XY4 | AAV2/9-hSyn-hSNCA-WPRE-pA | hSNCA |
NRYF-0624-XY5 | AAV2/1-CMV_bGI-hSNCA-WPRE-pA | hSNCA |
NRYF-0624-XY6 | AAV2/1-CMV_bGI-HA-hSNCA-WPRE-pA | hSNCA |
Alzheimer's disease (AD) modeling tools
AD brains exhibit extracellular plaques of amyloid β (Aβ) and intraneuronal neurofibrillary tangles (NFTs) made up of hyperphosphorylated Tau protein. Our scientific team has developed AAV-mediated gene expression through various delivery routes to construct AD models.
Cat. No. | Product Name | Functional Gene |
NRYF-0624-XY7 | rAAV-SYN-tau(p301L)-WPRE-bGHpA | Tau(p301L) |
NRYF-0624-XY8 | rAAV-SYN-APPs1-L-WPRE-bGHpA | APPs1-L |
NRYF-0624-XY9 | rAAV-SYN-PS1-M146L-WPRE-bGHpA | PS1-M146L |
NRYF-0624-XY10 | -rAAV--SYN-APPs1a-L-A-WPRE-bGHpA | APPs1a-L |
Amyotrophic lateral sclerosis (ALS) modeling tools
ALS is an adult-onset neurodegenerative disease, also known as Lou Gehrig's disease/motor neuron disease (MND), characterized by axonal degeneration leading to the destruction of nerve endings, resulting in the progressive loss of motor neurons. Our ALS modeling tools use AAV vectors to express TDP-43 via temporal vein injection and stereotactic brain injection to simulate some ALS symptoms and pathological features.
Cat. No. | Product Name | Functional Gene |
NRYF-0624-XY11 | rAAV-SYN-TDP-43-WPRE-bGHpA | TDP-43 |
NRYF-0624-XY12 | rAAV-SYN-TDP-43(M337V)-WPRE-bGHpA | TDP-43(M337V) |
NRYF-0624-XY13 | rAAV-SYN-TDP-25-WPRE-bGHpA | TDP-25 |
NRYF-0624-XY14 | rAAV-SYN-TDP-43∆NLS-WPRE-bGHpA | TDP-43∆NLS |
Advantages
- AAV vectors can be targeted at specific brain areas.
- AAV tools enable transgenic expression in adult animals, avoiding the effects of compensatory mechanisms during development.
- With AAV tools, you can generate disease models with different doses, different species (rodents, non-human primates), and different gene combinations.
- Models generated with AAV tools exhibited time-dependent neuropathologic changes (neuroinflammation and increased cytoplasmic inclusions).
- To meet different experimental needs, AAV tools offer more options: different AAV serotypes, different broad-spectrum or specific promoters, etc.
Creative Biolabs provides a variety of neurological disease-related viruses that are ready to use. To locate the product you require, please peruse our product list. In accordance with your experimental requirements, you can also freely combine serotypes, promoters, functional genes, and expression techniques. We are pleased to provide you with specialized products. To expedite your study on neurological diseases, please get in touch with us.
AAV packaging vector for EF1a driven OMOR expression.
- Tracer Type:
- Neurological Disease Related Virus
- Applications:
- Neural Circuit Mapping
Neuronal tracing
- Tracer Type:
- Neurological Disease Related Virus; Gene Therapy
- Applications:
- Neural Tracing
Neuronal tracing
- Tracer Type:
- Virus Vector/Partical
- Applications:
- Neural Tracing
- Tracer Type:
- Neurological Disease Related Virus
- Applications:
- Alzheimer's disease
- Tracer Type:
- Neurological Disease Related Virus
- Applications:
- Alzheimer's disease
Gene regulation
Ready-to-use AAV particles
- Tracer Type:
- Neurological Disease Related Virus
- Applications:
- Alzheimer's disease
Gene regulation
Ready-to-use AAV particles
- Tracer Type:
- Neurological Disease Related Virus
- Applications:
- Alzheimer's disease
Specific Promoter
- Tracer Type:
- Neurological Disease Related Virus
- Applications:
- Alzheimer's disease
Specific Promoter
- Tracer Type:
- Neurological Disease Related Virus
- Applications:
- Alzheimer's disease
Specific Promoter
- Tracer Type:
- Neurological Disease Related Virus
- Applications:
- Alzheimer's disease
Specific Promoter
- Tracer Type:
- Neurological Disease Related Virus
- Applications:
- Alzheimer's disease
Specific Promoter
- Tracer Type:
- Neurological Disease Related Virus
- Applications:
- Alzheimer's disease
Specific Promoter
- Tracer Type:
- Neurological Disease Related Virus
- Applications:
- Alzheimer's disease
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- NeuroMab™ Anti-Amyloid Beta 1-15 Antibody(NRP-0422-P867) (Cat#: NRP-0422-P867)
- NeuroMab™ Anti-ApoC3 BBB Shuttle Antibody(NRZP-1022-ZP3503) (Cat#: NRZP-1022-ZP3503)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2293) (Cat#: NRP-0422-P2293)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P1760) (Cat#: NRP-0422-P1760)
- NeuroMab™ Anti-pTau Antibody(NRP-0422-P1719) (Cat#: NRP-0422-P1719)
- NeuroMab™ Anti-F-Spondin/SPON1 Antibody, Clone N24875P (CBP11839) (Cat#: NRZP-0822-ZP4740)
- NeuroMab™ Anti-EPHB2 Antibody(NRP-0422-P1220) (Cat#: NRP-0422-P1220)
- NeuroMab™ Anti-CD20 Antibody(NRP-0422-P1230) (Cat#: NRP-0422-P1230)
- NeuroMab™ Anti-SEZ6 Antibody(NRP-0422-P517) (Cat#: NRP-0422-P517)
- iNeu™ Human Neural Stem Cell Line (Cat#: NCL200552ZP)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) (Cat#: NCL-2103-P49)
- Rat Immortalized Retinal Muller Cell Line rMC-1 (Cat#: NCL-2106-S93)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- Human Astrocytes (Cat#: NCC20-9PZ01)
- iNeu™ Retinal Pigment Epithelial Cells (RPE) (Cat#: NRZP-0323-ZP92)
- Rat Microglia Cell Line HAPI, Immortalized (Cat#: NCL2110P015)
- Immortalized Human Cerebral Microvascular Endothelial Cells (Cat#: NCL-2108-P020)
- Rat Muller Cell (Cat#: NCL2110P040)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- pAAV-syn-FLEX-jGCaMP8m-WPRE (Cat#: NTA-2106-P065)
- pAAV-EF1a-DIO-EGFP-WPRE (Cat#: NTA-2012AD-P285)
- rAAV-E-SARE-Cre-ERT2-PEST-WPRE-hGH polyA (Cat#: NTA-2010-TT342)
- rAAV-CAG-DIO-G-Flamp1 (Cat#: NRZP-0722-ZP719)
- AAV-mDLX-CRE-tdTomato (Cat#: NRZP-0622-ZP721)
- pAAV-syn-FLEX-jGCaMP8f-WPRE (Cat#: NTA-2106-P064)
- AAV2/9-hEF1a-fDIO-eNpHR 3.0-mCherry-WPRE-pA (Cat#: NTA-2012-ZP78)
- Dextran-FITC (Cat#: NTA-2011-ZP110)
- AAV2/9-hEF1a-DIO-mCherry-P2A-TetTox-WPRE-pA (Cat#: NTA-2012-ZP268)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)