Chemogenetic Tools
Chemogenetics, also known as pharmacogenetics, is a successful strategy for activating or inhibiting biological processes in specific cell types. Chemogenetic tools can be turned on or off by using small-molecule ligands to target the actuators of particular cell groups, most notably neurons. Creative Biolabs offers a wide range of viral tools based on designer receptors exclusively activated by designer drugs (DREADD) technology, including Gq, Gi, Gs, Golf, and β-arrestin. The most widely used ones are Gq-DREADD (hM3Dq) and Gi-DREADD (hM4Di). hM3Dq is often used to activate neurons, while hM4Di is often used to inhibit neuronal activity.
Chemogenetic Receptors
| Receptors | Description |
| Gq-DREADD (hM3Dq) | The human muscarinic acetylcholine receptor M3 was altered to create hM3Dq, a receptor that is no longer triggered by acetylcholine and only reacts to CNO (clozapine-N-oxide). The results of CNO-inducing hM3Dq are different in different cell types. In mature neurons, CNO induction of hM3Dq results in neuronal depolarization and increased neuronal excitability. In astrocytes, CNO induction of hM3Dq results in increased astrocytic Ca2+ release. |
| Gi-DREADD (hM4Di) | The human muscarinic acetylcholine receptor M4 is the source of the designed receptor hM4Di, which is no longer activated by acetylcholine and only reacts to CNO. The role of hM4D is altered in cells that do not express Gi or GIRK. Certain neurons experience hyperpolarization of the cell membrane and inhibition of the action potential of neuronal cells when CNO binds to hM4D and activates the Gi protein-coupled inward potassium ion channel GIRK. |
| KORD | KORD overcomes the limitation of DREADDs, which cannot perform bidirectional experiments, by responding to salvinorin B (SALB). Both KORD and hM3Dq can be used in the same organism to achieve bidirectional control of neuronal activity. |
Please browse through our related products list of chemogenetic to find the right chemogenetic tools for your experiment.
Advantages of DREADDs
- Simple steps and ease of use
- Prolonged neuronal activation or inhibition
- In drug development, DREADDs offer many opportunities
Creative Biolabs can provide packaging services for the following products. If the Adeno-Associated Viruses (AAV) you are searching for are not listed, please contact us right away. We can design and package AAV vectors to suit your individual research requirements.
For Research Use Only. Not For Clinical Use.
Related Products
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rAAV-RAM-d2TTA-TRE-hM4D(Gi)-mCherry [CAT#: NRZP-0722-ZP604]
Chemogenetics
Ready-to-use AAV particles
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AAV-Syn-FRT-hM3D(Gq)-mCherry [Chemogenetics] [CAT#: NRZP-0622-ZP760]
AAV packaging vector for Syn driven hM3D(Gq) expression.
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- Chemogenetics
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- Chemogenetics
AAV-hSyn-hM4D(Gi)-mCherry [Chemogenetics] [CAT#: NRZP-0622-ZP703]
AAV packaging vector for hSyn driven hM4D(Gi) expression.
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- Chemogenetics
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- Chemogenetics
AAV-hSyn-hM4D(Gi)-eYFP [Chemogenetics] [CAT#: NRZP-0622-ZP702]
AAV packaging vector for hSyn driven hM4D(Gi) expression.
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- Chemogenetics
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- Chemogenetics
AAV-hSyn-hM3D(Gq)-mCherry [Chemogenetics] [CAT#: NRZP-0622-ZP701]
AAV packaging vector for hSyn driven hM3D(Gq) expression.
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- Chemogenetics
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- Chemogenetics
AAV-hSyn-HA-hM3D(Gq)-IRES-mCitrine [Chemogenetics] [CAT#: NRZP-0622-ZP698]
AAV packaging vector for hSyn driven hM3D(Gq) expression.
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- Chemogenetics
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AAV-hSYN-FSF-DIO-HA-hM3D(Gq)-mCherry [Chemogenetics] [CAT#: NRZP-0622-ZP693]
AAV packaging vector for hSYN driven hM3D(Gq) expression.
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- Chemogenetics
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AAV-hSyn-fDIO-hM4D(Gi)-mCherry [Chemogenetics] [CAT#: NRZP-0622-ZP685]
AAV packaging vector for hSyn driven hM4D(Gi) expression.
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- Chemogenetics
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- Chemogenetics
AAV-hSyn-fDIO-hM3D(Gs)-mCherry [Chemogenetics] [CAT#: NRZP-0622-ZP684]
AAV packaging vector for hSyn driven hM3D(Gs) expression.
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- Chemogenetics
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- Chemogenetics
AAV-hSyn-fDIO-hM3D(Gq)-mCherry [Chemogenetics] [CAT#: NRZP-0622-ZP683]
AAV packaging vector for hSyn driven hM3D(Gq) expression.
- Tracer Type:
- Chemogenetics
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- Chemogenetics
AAV-hSyn-DlO-HA-hM4D(Gi)-IRES-mCitrine [Chemogenetics] [CAT#: NRZP-0622-ZP675]
AAV packaging vector for hSyn driven hM4D(Gi) expression.
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- Chemogenetics
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AAV-hSYN-DIO-rM3D(Gs)-mCherry [Chemogenetics] [CAT#: NRZP-0622-ZP671]
AAV packaging vector for hSYN driven rM3D(Gs) expression.
- Tracer Type:
- Chemogenetics
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AAV-hSYN-DIO-hM4D(Gi)-mCherry [Chemogenetics] [CAT#: NRZP-0622-ZP668]
AAV packaging vector for hSYN driven hM4D(Gi) expression.
- Tracer Type:
- Chemogenetics
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- Chemogenetics
AAV-hSYN-DIO-hM3D(Gq)-mCherry [Chemogenetics] [CAT#: NRZP-0622-ZP667]
AAV packaging vector for hSYN driven hM3D(Gq) expression.
- Tracer Type:
- Chemogenetics
- Applications:
- Chemogenetics
AAV-hSYN-DIO-HA-hM3D(Gq)-IRES-mCitrine [Chemogenetics] [CAT#: NRZP-0622-ZP665]
AAV packaging vector for hSYN driven hM3D(Gq) expression.
- Tracer Type:
- Chemogenetics
- Applications:
- Chemogenetics
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