Apoptosis/Killing Tools

Abnormalities in programmed cell death (PCD) signaling cascades, including apoptosis, necrosis, pyroptosis, ferroptosis, autophagy-related cell death, and non-programmed necrosis, can be observed in the pathogenesis of various neurological diseases. These cell deaths can occur in reaction to numerous types of cellular stress (caused by intracellular or extracellular stimuli) and inflammation. Aberrant activation of PCD pathways is a common feature of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, and Huntington's disease, leading to unexpected losses of neuronal cells and functions.

Our apoptosis/killing tools can help ablate target cells to study their specific functions. For in vivo model applications, apoptosis/killing tools can also simulate the abnormal activation of PCD pathways in neurodegenerative diseases, helping researchers to elucidate the underlying mechanisms of the disease and identify potential treatments for the disease.

Applications of Apoptosis/Killing Tools

• taCasp3-TEVp induces apoptosis

Casp3 protein is a cell apoptosis effector molecule. During cell apoptosis, molecules such as caspase-10 will cleave Casp3 between positions 175 and 176, activating the activity of Casp3. taCasp3 has the recognition site of TEVp inserted at this position, a specific serine protease derived from Tobacco Etch Virus. When expressed in cells, TEVp is first expressed and then activates Casp3, triggering a cascade reaction leading to apoptosis.

• Diphtheria toxin A (DTA) induces cell death

DTA is the fragment of diphtheria toxin, which can inhibit protein synthesis and cell death. DTA functional elements can be used to selectively eliminate specific cells to study the unique functions of these cells and are also widely used to model neurological diseases.

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Intellectual Property

Creative Biolabs is a contract manufacturer that produces tailored viruses and vectors according to client specifications. Importantly, this manufacturing service does not grant Creative Biolabs any intellectual property ownership; all designs and associated intellectual property rights remain exclusively with the customer.

Certain vector components may be subject to third-party intellectual property rights. Creative Biolabs offers publicly available sequence information for these components as a convenience for reference only. The customer assumes full responsibility and liability for the use of these components in their custom vectors. By purchasing vectors containing such components, the customer confirms they have secured all necessary intellectual property licenses, including the right to engage Creative Biolabs for manufacturing.