RNAi Tools

RNA interference (RNAi) tools introduce small fragments (19–23 bp) of exogenous double-stranded RNA (dsRNA) that are homologous to endogenous mRNA into cells, triggering efficient and specific degradation of the corresponding mRNA in cells, resulting in the silencing or knockdown of specific genes. RNAi is a mature technology that can effectively, rapidly and persistently disrupt gene expression in vivo using adeno-associated virus (AAV) viral vectors to express shRNA, siRNA and miRNA.

Applications

Application	Description
Research into the function of genes	RNAi is characterized by its high efficiency and targeted suppression of gene expression. Using AAV-mediated shRNA interference, gene expression can be regulated, and then gene function can be studied.
Research on signaling pathways	The features of AAV-mediated shRNA interference include a long duration, robust interference capacity, and wide host range. This technology can be used to study associated signal pathways and mechanisms of action in vivo and in vitro.
Disease model building	AAV-mediated shRNA interference can be used to target gene expression to generate transgenic mouse models, such as Alzheimer's disease models, Parkinson's disease models, and Huntington's disease models.
Gene therapy	AAV-mediated shRNA interference is used in the treatment of diseases caused by abnormally high levels of gene expression, such as tumors and viral infections.
Drug development	RNAi is used to specifically and efficiently inhibit gene expression, obtain a gene function inhibition phenotype, and then screen gene targets on a large scale, enabling rapid screening and evaluation of drug targets at the cellular and animal levels.

Product Advantages

A wide variety of vector types: Broad spectrum, as well as specific interference vectors, are available to meet your needs.
High diffusion: Our viral products can cross the blood-brain barrier and are ideal tools for the infection of neurons and glial cells.
High level of specificity: There are more than a dozen commonly used serotypes of rAAV, each of which is capable of recognizing and infecting different organs.
Long duration of expression: rAAV can be continuously expressed in tissues for more than 6 months.
Custom options: We can customize our products to meet your specific needs.

Creative Biolabs offers a range of ready-to-use AAV RNAi tools. We can also provide AAV vector design and construction services for RNAi delivery to meet your specific needs. Our team of professionals is at your disposal. If you are interested in any of our products or services, please contact us!

For Research Use Only. Not For Clinical Use.

Premade Viruses

rAAV-U6-shRNA(Scramble)-CMV-EGFP [CAT#: NTA-2012-WTT548]

Gene regulation

Tracer Type:: RNAi

Applications:: RNA interference

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