RNAi Tools
RNA interference (RNAi) tools introduce small fragments (19–23 bp) of exogenous double-stranded RNA (dsRNA) that are homologous to endogenous mRNA into cells, triggering efficient and specific degradation of the corresponding mRNA in cells, resulting in the silencing or knockdown of specific genes. RNAi is a mature technology that can effectively, rapidly and persistently disrupt gene expression in vivo using adeno-associated virus (AAV) viral vectors to express shRNA, siRNA and miRNA.
Applications
| Application | Description |
| Research into the function of genes | RNAi is characterized by its high efficiency and targeted suppression of gene expression. Using AAV-mediated shRNA interference, gene expression can be regulated, and then gene function can be studied. |
| Research on signaling pathways | The features of AAV-mediated shRNA interference include a long duration, robust interference capacity, and wide host range. This technology can be used to study associated signal pathways and mechanisms of action in vivo and in vitro. |
| Disease model building | AAV-mediated shRNA interference can be used to target gene expression to generate transgenic mouse models, such as Alzheimer's disease models, Parkinson's disease models, and Huntington's disease models. |
| Gene therapy | AAV-mediated shRNA interference is used in the treatment of diseases caused by abnormally high levels of gene expression, such as tumors and viral infections. |
| Drug development | RNAi is used to specifically and efficiently inhibit gene expression, obtain a gene function inhibition phenotype, and then screen gene targets on a large scale, enabling rapid screening and evaluation of drug targets at the cellular and animal levels. |
Product Advantages
- A wide variety of vector types: Broad spectrum, as well as specific interference vectors, are available to meet your needs.
- High diffusion: Our viral products can cross the blood-brain barrier and are ideal tools for the infection of neurons and glial cells.
- High level of specificity: There are more than a dozen commonly used serotypes of rAAV, each of which is capable of recognizing and infecting different organs.
- Long duration of expression: rAAV can be continuously expressed in tissues for more than 6 months.
- Custom options: We can customize our products to meet your specific needs.
Creative Biolabs offers a range of ready-to-use AAV RNAi tools. We can also provide AAV vector design and construction services for RNAi delivery to meet your specific needs. Our team of professionals is at your disposal. If you are interested in any of our products or services, please contact us!
For Research Use Only. Not For Clinical Use.
Related Products
Loading...
rAAV-EF1α-mCherry-U6-Loxp-CMV-EGFP-Loxp-shRNA(Scramble) [CAT#: NTA-2012-WTT550]
Gene regulation
Ready-to-use AAV particles
- Tracer Type:
- RNAi
- Applications:
- RNA interference
rAAV-U6-shRNA(Scramble)-CMV-mCherry [CAT#: NTA-2012-WTT549]
Gene regulation
Ready-to-use AAV particles
- Tracer Type:
- RNAi
- Applications:
- RNA interference
- Tracer Type:
- RNAi
- Applications:
- RNA interference
rAAV-U6-Loxp-CMV-mCherry-SV40 polyA-Loxp-shRNA(Scramble) [CAT#: NTA-2012-WTT547]
Gene regulation
Ready-to-use AAV particles
- Tracer Type:
- RNAi
- Applications:
- RNA interference
rAAV-GFAP-EGFP-5'miR-30a-shRNA(Scramble)-3'miR-30a [CAT#: NTA-2012-WTT546]
Gene regulation
Ready-to-use AAV particles
- Tracer Type:
- RNAi
- Applications:
- RNA interference
rAAV-hSyn-EGFP-5'miR-30a-shRNA(Scramble)-3'miR-30a [CAT#: NTA-2012-WTT545]
Gene regulation
Ready-to-use AAV particles
- Tracer Type:
- RNAi
- Applications:
- RNA interference
AAV2/4-H1-shRNA(Luciferase)-CAG-mCherry-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP442]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/Anco80L65-CAG-miRNAi-EGFP-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP441]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/5-gfaABC1D-mCherry-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP440]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/5-H1-shRNA(Luciferase)-CAG-EGFP-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP439]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/5-H1-shRNA(Luciferase)-CAG-EGFP-pA [Gene Regulation] [CAT#: NTA-2012-ZP438]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-H1-shRNA(Luciferase)-CAG-EGFP-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP436]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-U6-shRNA(Luciferase)-CAG-mCherry-pA [Gene Regulation] [CAT#: NTA-2012-ZP435]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-U6-shRNA(Luciferase)-CAG-EGFP-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP434]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-hEF1a-DIO-EGFP-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP432]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-hTBG-miRNAi(NC)-pA [Gene Regulation] [CAT#: NTA-2012-ZP430]
RNA interference Control
- Tracer Type:
- RNAi; CRISPR/Cas9 system
- Applications:
- Gene Regulation
AAV2/8-H1-gRNA/shRNA(MCS)-CAG-ffLuciferase-WPRE-pA [Control] [CAT#: NTA-2012-ZP429]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Control
AAV2/8-gfaABC1D-mCherry-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP428]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-hTBG-miRNAi(NC) -WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP427]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-CMV_bGI-EGFP-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP426]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-hTBG-Cre-EGFP-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP425]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-hTBG-EGFP-miRNAi(NC) [Gene Regulation] [CAT#: NTA-2012-ZP424]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-gfaABC1D-EBFP-miRNAi(NC1)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP423]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-mDlx -mCherry-miRNAi(NC) -WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP422]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-hTNNT2_rhi-EGFP-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP421]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-cTNT_rhi-EGFP-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP420]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-U6-shRNA(Luciferase)-CAG-mCherry-pA [Gene Regulation] [CAT#: NTA-2012-ZP419]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-U6-shRNA(Luciferase)-CAG-EGFP-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP418]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-H1-shRNA(Luciferase)-CAG-EGFP-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP417]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-CMV_bGI-ffLuciferase-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP416]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
Product
Hot Products
Antibodies
- NeuroMab™ Anti-pTau Antibody(NRP-0422-P1719) (Cat#: NRP-0422-P1719)
- NeuroMab™ Anti-SEZ6 Antibody(NRP-0422-P515) (Cat#: NRP-0422-P515)
- NeuroMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- NeuroMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2293) (Cat#: NRP-0422-P2293)
- NeuroMab™ Anti-GARP Antibody(NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- NeuroMab™ Anti-CD32b Antibody(NRP-0422-P1803) (Cat#: NRP-0422-P1803)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- NeuroMab™ Anti-CD20 Antibody(NRP-0422-P1230) (Cat#: NRP-0422-P1230)
- NeuroMab™ Anti-F-Spondin/SPON1 Antibody, Clone N24875P (CBP11839) (Cat#: NRZP-0822-ZP4740)
Cells
- Rat Immortalized Retinal Muller Cell Line rMC-1 (Cat#: NCL-2106-S93)
- Mouse Glioma Cell Line GL261 (Cat#: NCL-2108P28)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Rat Retinal Muller Cell Line, Immortalized (Cat#: NCL-21P6-192)
- iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) (Cat#: NCL-2103-P49)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Rat Schwann Cells RSC96, Immortalized (Cat#: NCL-2108P21)
- iNeu™ Retinal Pigment Epithelial Cells (RPE) (Cat#: NRZP-0323-ZP92)
- iNeu™ Microglia (Cat#: NCL-7P018)
- Human Astrocytes, Immortalized (Cat#: NCL-2105-P182-AM)
Kits
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
Tracers
- pAAV-syn-FLEX-jGCaMP8m-WPRE (Cat#: NTA-2106-P065)
- AAV2/9-hEF1a-DIO-mCherry-P2A-TetTox-WPRE-pA (Cat#: NTA-2012-ZP268)
- PRV-CAG-EGFP (Cat#: NTA-2011-ZP14)
- pAAV-syn-jGCaMP8m-WPRE (Cat#: NTA-2106-P062)
- pAAV-syn-jGCaMP8s-WPRE (Cat#: NTA-2106-P063)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- Dextran-CYanine5.5 (Cat#: NTA-2011-ZP118)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- AAV2/2Retro-CAG-DIO-EGFP-2A-TetTox-pA [Neural Tracing] (Cat#: NTA-2012-ZP303)
- Dextran, NHS Activated, 40 kDa (Cat#: NRZP-0722-ZP124)
Gene Related Products
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
Biospecimens
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
Cell Assay Reagents
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
