RNAi Tools
RNA interference (RNAi) tools introduce small fragments (19–23 bp) of exogenous double-stranded RNA (dsRNA) that are homologous to endogenous mRNA into cells, triggering efficient and specific degradation of the corresponding mRNA in cells, resulting in the silencing or knockdown of specific genes. RNAi is a mature technology that can effectively, rapidly and persistently disrupt gene expression in vivo using adeno-associated virus (AAV) viral vectors to express shRNA, siRNA and miRNA.
Applications
| Application | Description |
| Research into the function of genes | RNAi is characterized by its high efficiency and targeted suppression of gene expression. Using AAV-mediated shRNA interference, gene expression can be regulated, and then gene function can be studied. |
| Research on signaling pathways | The features of AAV-mediated shRNA interference include a long duration, robust interference capacity, and wide host range. This technology can be used to study associated signal pathways and mechanisms of action in vivo and in vitro. |
| Disease model building | AAV-mediated shRNA interference can be used to target gene expression to generate transgenic mouse models, such as Alzheimer's disease models, Parkinson's disease models, and Huntington's disease models. |
| Gene therapy | AAV-mediated shRNA interference is used in the treatment of diseases caused by abnormally high levels of gene expression, such as tumors and viral infections. |
| Drug development | RNAi is used to specifically and efficiently inhibit gene expression, obtain a gene function inhibition phenotype, and then screen gene targets on a large scale, enabling rapid screening and evaluation of drug targets at the cellular and animal levels. |
Product Advantages
- A wide variety of vector types: Broad spectrum, as well as specific interference vectors, are available to meet your needs.
- High diffusion: Our viral products can cross the blood-brain barrier and are ideal tools for the infection of neurons and glial cells.
- High level of specificity: There are more than a dozen commonly used serotypes of rAAV, each of which is capable of recognizing and infecting different organs.
- Long duration of expression: rAAV can be continuously expressed in tissues for more than 6 months.
- Custom options: We can customize our products to meet your specific needs.
Creative Biolabs offers a range of ready-to-use AAV RNAi tools. We can also provide AAV vector design and construction services for RNAi delivery to meet your specific needs. Our team of professionals is at your disposal. If you are interested in any of our products or services, please contact us!
For Research Use Only. Not For Clinical Use.
Related Products
Loading...
rAAV-EF1α-mCherry-U6-Loxp-CMV-EGFP-Loxp-shRNA(Scramble) [CAT#: NTA-2012-WTT550]
Gene regulation
Ready-to-use AAV particles
- Tracer Type:
- RNAi
- Applications:
- RNA interference
rAAV-U6-shRNA(Scramble)-CMV-mCherry [CAT#: NTA-2012-WTT549]
Gene regulation
Ready-to-use AAV particles
- Tracer Type:
- RNAi
- Applications:
- RNA interference
- Tracer Type:
- RNAi
- Applications:
- RNA interference
rAAV-U6-Loxp-CMV-mCherry-SV40 polyA-Loxp-shRNA(Scramble) [CAT#: NTA-2012-WTT547]
Gene regulation
Ready-to-use AAV particles
- Tracer Type:
- RNAi
- Applications:
- RNA interference
rAAV-GFAP-EGFP-5'miR-30a-shRNA(Scramble)-3'miR-30a [CAT#: NTA-2012-WTT546]
Gene regulation
Ready-to-use AAV particles
- Tracer Type:
- RNAi
- Applications:
- RNA interference
rAAV-hSyn-EGFP-5'miR-30a-shRNA(Scramble)-3'miR-30a [CAT#: NTA-2012-WTT545]
Gene regulation
Ready-to-use AAV particles
- Tracer Type:
- RNAi
- Applications:
- RNA interference
AAV2/4-H1-shRNA(Luciferase)-CAG-mCherry-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP442]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/Anco80L65-CAG-miRNAi-EGFP-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP441]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/5-gfaABC1D-mCherry-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP440]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/5-H1-shRNA(Luciferase)-CAG-EGFP-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP439]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/5-H1-shRNA(Luciferase)-CAG-EGFP-pA [Gene Regulation] [CAT#: NTA-2012-ZP438]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-H1-shRNA(Luciferase)-CAG-EGFP-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP436]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-U6-shRNA(Luciferase)-CAG-mCherry-pA [Gene Regulation] [CAT#: NTA-2012-ZP435]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-U6-shRNA(Luciferase)-CAG-EGFP-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP434]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-hEF1a-DIO-EGFP-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP432]
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-hTBG-miRNAi(NC)-pA [Gene Regulation] [CAT#: NTA-2012-ZP430]
RNA interference Control
- Tracer Type:
- RNAi; CRISPR/Cas9 system
- Applications:
- Gene Regulation
AAV2/8-H1-gRNA/shRNA(MCS)-CAG-ffLuciferase-WPRE-pA [Control] [CAT#: NTA-2012-ZP429]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Control
AAV2/8-gfaABC1D-mCherry-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP428]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-hTBG-miRNAi(NC) -WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP427]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-CMV_bGI-EGFP-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP426]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-hTBG-Cre-EGFP-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP425]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-hTBG-EGFP-miRNAi(NC) [Gene Regulation] [CAT#: NTA-2012-ZP424]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/8-gfaABC1D-EBFP-miRNAi(NC1)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP423]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-mDlx -mCherry-miRNAi(NC) -WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP422]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-hTNNT2_rhi-EGFP-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP421]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-cTNT_rhi-EGFP-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP420]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-U6-shRNA(Luciferase)-CAG-mCherry-pA [Gene Regulation] [CAT#: NTA-2012-ZP419]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-U6-shRNA(Luciferase)-CAG-EGFP-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP418]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-H1-shRNA(Luciferase)-CAG-EGFP-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP417]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
AAV2/9-CMV_bGI-ffLuciferase-miRNAi(NC)-WPRE-pA [Gene Regulation] [CAT#: NTA-2012-ZP416]
RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
Product
Hot Products
Antibodies
- NeuroMab™ Anti-CD20 Antibody(NRP-0422-P1230) (Cat#: NRP-0422-P1230)
- NeuroMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- NeuroMab™ Anti-ApoC3 BBB Shuttle Antibody(NRZP-1022-ZP3505) (Cat#: NRZP-1022-ZP3505)
- NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody(NRZP-1022-ZP4050) (Cat#: NRZP-1022-ZP4050)
- NeuroMab™ Anti-SEZ6 Antibody(NRP-0422-P515) (Cat#: NRP-0422-P515)
- NeuroMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- NeuroMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- NeuroMab™ Anti-TREM2 BBB Shuttle Antibody(NRZP-1022-ZP4114) (Cat#: NRZP-1022-ZP4114)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- NeuroMab™ Anti-F-Spondin/SPON1 Antibody, Clone N24875P (CBP11839) (Cat#: NRZP-0822-ZP4740)
Cells
- Mouse Glioma Cell Line GL261-GFP (Cat#: NCL-2108P04)
- Human Neurons Isolated from Cortex (Cat#: NCL-21P6-023)
- Mouse Retinal Ganglion Cell Line RGC-5 (Cat#: NCL2110P154)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Human Brain Vascular Adventitial Fibroblasts (Cat#: NCL-21P6-014)
- Human Astrocytes (Cat#: NCC20-9PZ01)
- Green Fluorescent Alpha-synuclein SH-SY5Y Cell Line (Cat#: NCL2110P209)
- Mouse Midbrain Dopaminergic Neuron Cell MN9D (Cat#: NCL2110P059)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
Kits
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
Tracers
- Dextran, NHS Activated, 40 kDa (Cat#: NRZP-0722-ZP124)
- pAAV-syn-FLEX-jGCaMP8m-WPRE (Cat#: NTA-2106-P065)
- pAAV-EF1a-DIO-EGFP-WPRE (Cat#: NTA-2012AD-P285)
- AAV2/9-hEF1a-DIO-mCherry-P2A-TetTox-WPRE-pA (Cat#: NTA-2012-ZP268)
- rAAV-CAG-DIO-G-Flamp1 (Cat#: NRZP-0722-ZP719)
- AAV2/2Retro-CAG-DIO-EGFP-2A-TetTox-pA [Neural Tracing] (Cat#: NTA-2012-ZP303)
- Dextran, Cy5 Labeled, 2000 kDa (Cat#: NRZP-0722-ZP22)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- rAAV-E-SARE-Cre-ERT2-PEST-WPRE-hGH polyA (Cat#: NTA-2010-TT342)
- AAV-mDLX-CRE-tdTomato (Cat#: NRZP-0622-ZP721)
Gene Related Products
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
Biospecimens
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
Cell Assay Reagents
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
