RNAi Tools

RNA interference (RNAi) tools introduce small fragments (19–23 bp) of exogenous double-stranded RNA (dsRNA) that are homologous to endogenous mRNA into cells, triggering efficient and specific degradation of the corresponding mRNA in cells, resulting in the silencing or knockdown of specific genes. RNAi is a mature technology that can effectively, rapidly and persistently disrupt gene expression in vivo using adeno-associated virus (AAV) viral vectors to express shRNA, siRNA and miRNA.

Applications

Application	Description
Research into the function of genes	RNAi is characterized by its high efficiency and targeted suppression of gene expression. Using AAV-mediated shRNA interference, gene expression can be regulated, and then gene function can be studied.
Research on signaling pathways	The features of AAV-mediated shRNA interference include a long duration, robust interference capacity, and wide host range. This technology can be used to study associated signal pathways and mechanisms of action in vivo and in vitro.
Disease model building	AAV-mediated shRNA interference can be used to target gene expression to generate transgenic mouse models, such as Alzheimer's disease models, Parkinson's disease models, and Huntington's disease models.
Gene therapy	AAV-mediated shRNA interference is used in the treatment of diseases caused by abnormally high levels of gene expression, such as tumors and viral infections.
Drug development	RNAi is used to specifically and efficiently inhibit gene expression, obtain a gene function inhibition phenotype, and then screen gene targets on a large scale, enabling rapid screening and evaluation of drug targets at the cellular and animal levels.

Advantages

Versatile Vector Options: Choose from broad-spectrum or highly specific interference vectors tailored to your research.
Enhanced Brain Permeability: Achieve efficient neuronal and glial cell infection with vectors capable of crossing the blood-brain barrier.
Targeted Tissue Specificity: Leverage a variety of rAAV serotypes for precise organ-specific infection.
Sustained Gene Expression: Ensure long-term experimental outcomes with rAAV vectors capable of continuous tissue expression for over 6 months.
Tailored Solutions: Benefit from customized services designed to meet your unique research requirements.

Creative Biolabs offers a range of premade AAV RNAi tools. We can also provide AAV vector design and construction services for RNAi delivery to meet your specific needs. Our team of professionals is at your disposal. If you are interested in any of our products or services, please contact us!

Intellectual Property

Creative Biolabs is a contract manufacturer that produces tailored viruses and vectors according to client specifications. Importantly, this manufacturing service does not grant Creative Biolabs any intellectual property ownership; all designs and associated intellectual property rights remain exclusively with the customer.

Certain vector components may be subject to third-party intellectual property rights. Creative Biolabs offers publicly available sequence information for these components as a convenience for reference only. The customer assumes full responsibility and liability for the use of these components in their custom vectors. By purchasing vectors containing such components, the customer confirms they have secured all necessary intellectual property licenses, including the right to engage Creative Biolabs for manufacturing.

For Research Use Only. Not For Clinical Use.

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