RNAi Tools
RNA interference (RNAi) tools introduce small fragments (19–23 bp) of exogenous double-stranded RNA (dsRNA) that are homologous to endogenous mRNA into cells, triggering efficient and specific degradation of the corresponding mRNA in cells, resulting in the silencing or knockdown of specific genes. RNAi is a mature technology that can effectively, rapidly and persistently disrupt gene expression in vivo using adeno-associated virus (AAV) viral vectors to express shRNA, siRNA and miRNA.
Applications
Application | Description |
Research into the function of genes | RNAi is characterized by its high efficiency and targeted suppression of gene expression. Using AAV-mediated shRNA interference, gene expression can be regulated, and then gene function can be studied. |
Research on signaling pathways | The features of AAV-mediated shRNA interference include a long duration, robust interference capacity, and wide host range. This technology can be used to study associated signal pathways and mechanisms of action in vivo and in vitro. |
Disease model building | AAV-mediated shRNA interference can be used to target gene expression to generate transgenic mouse models, such as Alzheimer's disease models, Parkinson's disease models, and Huntington's disease models. |
Gene therapy | AAV-mediated shRNA interference is used in the treatment of diseases caused by abnormally high levels of gene expression, such as tumors and viral infections. |
Drug development | RNAi is used to specifically and efficiently inhibit gene expression, obtain a gene function inhibition phenotype, and then screen gene targets on a large scale, enabling rapid screening and evaluation of drug targets at the cellular and animal levels. |
Advantages
- Versatile Vector Options: Choose from broad-spectrum or highly specific interference vectors tailored to your research.
- Enhanced Brain Permeability: Achieve efficient neuronal and glial cell infection with vectors capable of crossing the blood-brain barrier.
- Targeted Tissue Specificity: Leverage a variety of rAAV serotypes for precise organ-specific infection.
- Sustained Gene Expression: Ensure long-term experimental outcomes with rAAV vectors capable of continuous tissue expression for over 6 months.
- Tailored Solutions: Benefit from customized services designed to meet your unique research requirements.
Creative Biolabs offers a range of premade AAV RNAi tools. We can also provide AAV vector design and construction services for RNAi delivery to meet your specific needs. Our team of professionals is at your disposal. If you are interested in any of our products or services, please contact us!
Intellectual Property
Creative Biolabs is a contract manufacturer that produces tailored viruses and vectors according to client specifications. Importantly, this manufacturing service does not grant Creative Biolabs any intellectual property ownership; all designs and associated intellectual property rights remain exclusively with the customer.
Certain vector components may be subject to third-party intellectual property rights. Creative Biolabs offers publicly available sequence information for these components as a convenience for reference only. The customer assumes full responsibility and liability for the use of these components in their custom vectors. By purchasing vectors containing such components, the customer confirms they have secured all necessary intellectual property licenses, including the right to engage Creative Biolabs for manufacturing.


Gene regulation
- Tracer Type:
- RNAi
- Applications:
- RNA interference

Gene regulation
- Tracer Type:
- RNAi
- Applications:
- RNA interference

RNA interference Control
- Tracer Type:
- RNAi; CRISPR/Cas9 system
- Applications:
- Gene Regulation

RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation

RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation

RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation

RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation

RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation

RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation

RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation

RNA interference Control
- Tracer Type:
- RNAi
- Applications:
- Gene Regulation
- iNeuMab™ Anti-GD2 Antibody (NRZP-1222-ZP767) (Cat#: NRZP-1222-ZP767)
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- iNeuMab™ Anti-CD32b Antibody (NRP-0422-P1803) (Cat#: NRP-0422-P1803)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P1683) (Cat#: NRP-0422-P1683)
- iNeuMab™ Anti-TREM2 Antibody (NRP-0422-P792) (Cat#: NRP-0422-P792)
- iNeuMab™ Anti-CD20 Antibody (NRP-0422-P1230) (Cat#: NRP-0422-P1230)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- iNeuMab™ Anti-GARP Antibody (NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- Mouse Glioma Cell Line GL261 (Cat#: NCL-2108P28)
- Green Fluorescent Tau cell Line (Cat#: NCL2110P219)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- iNeu™ Human Schwann Cell (Cat#: NCL-2103-P63)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Rat Immortalized Retinal Muller Cell Line rMC-1 (Cat#: NCL-2106-S93)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Mouse Retinal Ganglion Cells (Cat#: NCL2110P145)
- Human Astrocytes, Immortalized (Cat#: NCL-2105-P182-AM)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)