Product
NeuroMab™ Anti-JIP-2/IB-2 BBB Shuttle Antibody, Clone N135/37
[CAT#: NRZP-0423-ZP180]
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-MAPK8IP2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 226-421 of mouse JIP-2/IB-2 (also known as C-junamino-terminal kinase-interacting protein 2, JNK-interacting protein 2, JNK MAP kinase scaffold protein 2, Islet-brain-2 and Mitogen-activated protein kinase 8-interacting protein 2, accession number Q9ERE9)
Rat: 94% identity (127/135 amino acids identical)
Human: 86% identity (173/200 amino acids identical)
>50% identity with JIP-1
Rat: 94% identity (127/135 amino acids identical)
Human: 86% identity (173/200 amino acids identical)
>50% identity with JIP-1
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Mouse; Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N135/37
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with JIP-1/IB-1
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
MAPK8IP2
Official Name
MAPK8IP2
Full Name
JIP-2/IB-2
Alternative Names
MAPK8IP2; IB-2; IB2; JIP2; PRKM8IPL; mitogen-activated protein kinase 8 interacting protein 2
Uniprot ID
Q9ERE9
Product Pictures
IB
Fig. 1 Immunoblot versus extracts from various WT (+/+) and IB2 KO (-/-) mouse brain regions probed with N135/37.
IB
Fig. 2 tissue and transfected cell immunoblot: extracts of adult rat brain membrane RBM and COS cells transiently transfected with Flagtagged JIP-1, JIP-2 or untagged Kv2.1 plasmid and probed with N135/37 (left), mouse anti-Flag (middle) and N52A/42 (right).
IHC
Fig. 3 Adult rat brain immunohistochemistry.
IB
Fig. 4 Adult rat brain membrane immunoblot.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
