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Creative Biolabs
Product

NeuroMab™ Anti-Nav1.9 BBB Shuttle Antibody, Clone 3881.2

[CAT#: NRZP-1022-ZP2505]

Host Species:
Rabbit
Species Reactivity:
Human; Cynomolgus Monkey
Applications:
ELISA; FC; IHC; In Vitro; In Vivo

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Cynomolgus Monkey

Clonality

Monoclonal

Host Species

Rabbit

Clone Number

3881.2

Applications

ELISA; FC; IHC; In Vitro; In Vivo
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

SCN11A

Official Name

SCN11A

Full Name

Sodium Voltage-Gated Channel Alpha Subunit 11

Alternative Names

SCN11A; FEPS3; HSAN7; NAV1.9; NaN; PN5; SCN12A; SNS-2; sodium voltage-gated channel alpha subunit 11
Product Pictures
IF

Fig.1 shows the immunostaining of a sub-odonblastic plexus sample (coronary dental pulp) cryofixed with an antibody 3881.1.

Human whole blood from three donors (26027, 26028, 26031) was stained with a-GalCer-loaded CD Id tetramer, 6B11-FITC or NKTT120-FITC in conjunction with anti-CD3 and anti-Va24 mAbs. Red blood cells were subsequently lysed and cells analyzed by flow cytometry. Cells shown are gated on CD3+ lymphocytes.

IF

Fig.2 shows the immunostaining of a cryofixed root canal sample of dental pulp with antibody 3881.1.

Human whole blood from three donors (26027, 26028, 26031) was stained with a-GalCer-loaded CD Id tetramer, 6B11-FITC or NKTT120-FITC in conjunction with anti-CD3 and anti-Va24 mAbs. Red blood cells were subsequently lysed and cells analyzed by flow cytometry. Cells shown are gated on CD3+ lymphocytes.

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For Research Use Only. Not For Clinical Use.
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