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Creative Biolabs
Product

NeuroMab™ Anti-OPGL Antibody, Clone αOPGL-1

[CAT#: NRP-0422-P1472]

Functional antibody against Human, Cynomolgus Monkey OPGL

Host Species:
Mouse
Species Reactivity:
Human; Cynomolgus Monkey
Applications:
ELISA; Inhib; In Vitro; Neut

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Product Overview

Description

αOPGL-1 binds specifically to OPGL and shows neutralizing activity. The potency of αOPGL-1 is also demonstrated by its ability to block the binding of OPG ligand to its cognate receptor, the osteoclast differentiation and activating receptor (ODAR, also known as RANK).

Immunogen

full-length human OPGL

Species Reactivity

Human; Cynomolgus Monkey

Clonality

Monoclonal

Host Species

Mouse

Clone Number

αOPGL-1

Applications

ELISA; Inhib; In Vitro; Neut
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

OPGL

Official Name

TNFSF11

Full Name

tumor necrosis factor ligand superfamily member 11

Alternative Names

TNFSF11; CD254; ODF; OPGL; OPTB2; RANKL; TRANCE; hRANKL2; sOdf; TNLG6B; tumor necrosis factor superfamily member 11; TNF superfamily member 11

Gene ID

Uniprot ID

Product Pictures
ELISA

Figure 1 shows the dose-dependent binding of αOPGL-1 to OPGL-coated EIA plates.

ELISA

Figure 2 shows the specific binding of [alpha]OPGL-1 to membrane-bound OPGL.

Inhib

Figure 3 shows the dose-dependent inhibition of osteoclastogenesis by αOPGL-1.

FuncS

Figure 4 shows the mean serum concentration time profile following a single dose of αOPGL-1 to cynomolgus monkeys.

FuncS

Figure 5 shows the mean percent change in serum N-Tx concentration following a single dose of αOPGL-1 to cynomolgus monkeys.

FuncS

Figure 6 shows the mean percent change in urinary N-Tx concentrations following a single dose of αOPGL-1 administered to cynomolgus monkeys.

ELISA

Figure 7 shows the inhibition of αOPGL-1 binding to OPGL-coated EIA plates by soluble OPGL.

ELISA

Figure 8 shows the specific binding of αOPGL-1 to OPGL-coated EIA plates.

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