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Creative Biolabs
Product

NeuroMab™ Anti-OPGL BBB Shuttle Antibody, Clone αOPGL-1

[CAT#: NRZP-1022-ZP2872]

Host Species:
Mouse
Species Reactivity:
Human; Cynomolgus Monkey
Applications:
ELISA; Inhib; In Vitro; Neut

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Immunogen

full-length human OPGL

Species Reactivity

Human; Cynomolgus Monkey

Clonality

Monoclonal

Host Species

Mouse

Clone Number

αOPGL-1

Applications

ELISA; Inhib; In Vitro; Neut
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

OPGL

Official Name

TNFSF11

Full Name

tumor necrosis factor ligand superfamily member 11

Alternative Names

TNFSF11; CD254; ODF; OPGL; OPTB2; RANKL; TRANCE; hRANKL2; sOdf; TNLG6B; tumor necrosis factor superfamily member 11; TNF superfamily member 11
Product Pictures
ELISA

Figure 1 shows the dose-dependent binding of αOPGL-1 to OPGL-coated EIA plates.

ELISA

Figure 2 shows the specific binding of [alpha]OPGL-1 to membrane-bound OPGL.

Inhib

Figure 3 shows the dose-dependent inhibition of osteoclastogenesis by αOPGL-1.

FuncS

Figure 4 shows the mean serum concentration time profile following a single dose of αOPGL-1 to cynomolgus monkeys.

FuncS

Figure 5 shows the mean percent change in serum N-Tx concentration following a single dose of αOPGL-1 to cynomolgus monkeys.

FuncS

Figure 6 shows the mean percent change in urinary N-Tx concentrations following a single dose of αOPGL-1 administered to cynomolgus monkeys.

ELISA

Figure 7 shows the inhibition of αOPGL-1 binding to OPGL-coated EIA plates by soluble OPGL.

ELISA

Figure 8 shows the specific binding of αOPGL-1 to OPGL-coated EIA plates.

Publications

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For Research Use Only. Not For Clinical Use.
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