Product
NeuroMab™ Anti-PAR-2 BBB Shuttle Antibody, Clone NR278P
[CAT#: NRZP-1022-ZP3891]
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- FC; WB; Antagonist
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Humanized
Clone Number
NR278P
Applications
FC; WB; Antagonist
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
PAR-2
Official Name
F2RL1
Full Name
Protease activated receptor 2
Alternative Names
GFAP
Product Pictures
WB
Figure 1 provides a Western blot comparing the binding of several full-length PAR-2 to PAR30 2 antibodies with cutoff PAR-2/Fc.
FuncS
Figure 2 demonstrates the ability of PAR-2 antibodies to produce antagonism of PAR-2 activation in a FLIPR assay using various cells expressing PAR-2.
WB
Figure 3 shows the Western blot results of antagonistic PAR-2 antibodies as well as antibodies that do not produce PAR-2 antagonism.
FLIPR Assay
Figure 4 compares the ability of several PAR-2 antibodies to produce PAR-2 activation antagonism in the FLIPR assay.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
