NeuroMab™ Anti-PHF Tau BBB Shuttle Antibody, Clone AT180

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Clone Number

AT180

Applications

ELISA; WB; In Vitro

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

PHF Tau

Full Name

Paired helical filament-tau

Alternative Names

PHF-Tau; MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40

Product Pictures

ELISA

Figure 1 Detection of PHF-tau and normal tau using monoclonal antibody AT180.

ELISA

Figure 2 Phosphorylation of wild-type and mutant recombinant tau (expressed from clone human tau 24; Goedert and Jakes, 1990) and protein kinase activity in rat brain.

Immunoblots with anti-tau antiserum 134 and monoclonal antibodies AT8 and AT180. Lanes 1, tau 24; 2, tau 24 plus brain extract; 3, T231 A tau 24; 4, T231 A tau 24 plus brain extract, 5, 5235 A tau 24; 6, S235 A tau 24 plus brain extract.

Publications