NeuroMab™ Anti-Synaptophysin BBB Shuttle Antibody, Clone RB2-4

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Immunogen

rat brain extract

Species Reactivity

Rat

Clonality

Monoclonal

Host Species

Mouse

Clone Number

RB2-4

Applications

WB; IHC; IP; ELISA

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Synaptophysin

Official Name

SYP

Full Name

Synaptophysin

Alternative Names

C5AR1

Product Pictures

SDS-PAGE

Fig.1 is a photograph showing the SDS-PAGE development pattern of a rat brain homogenate and specificity of a monoclonal antibody.

EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.

Publications