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Creative Biolabs
Product

NeuroMab™ Anti-Tau (K280-ac) Antibody, Clone ADEL-Y01m

[CAT#: NRP-0422-P1744]

Functional antibody against Human, Mouse Tau (K280-ac)

Host Species:
Mouse
Species Reactivity:
Human; Mouse
Applications:
ELISA; Block; Inhib; In Vitro; In Vivo

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Product Overview

Description

The anti-tau antibody specifically binds to tau protein in which the 280 thlysine is acetylated, and can inhibit the aggregation of abnormal tau protein. The anti-tau antibody is administered to an animal model that causes dementia, it is possible to improve the motor ability and cognitive ability of the animal model. Therefore, the anti-tau antibody according to the present invention can be usefully used in the prevention or treatment of neurodegenerative diseases.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Clone Number

ADEL-Y01m

Applications

ELISA; Block; Inhib; In Vitro; In Vivo
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

Tau (K280-ac)

Official Name

Tau (K280-ac)

Alternative Names

MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40; phosphorylated tau

Gene ID

4137(Human); 17762(Mouse); 29477(Rat)

Uniprot ID

P10636(Human); P10637(Mouse); P19332(Rat)
Product Pictures
FuncS

Figure 1 is a graph showing the results of a nesting test after administration of ADEL-Y01m antibody to a mouse model of ventricular dementia (***p<0.001).

FuncS

Figure 2 is a graph showing the results of Y-maze test after intracerebroventricular administration of ADEL-Y01m antibody to a dementia mouse model (*p<0.05).

FuncS

Figure 3 is a graph showing the results of a water maze test after administration of an ADEL-Y01m antibody to a mouse model of ventricular dementia.

FuncS

Figure 4 is a graph showing the residence time in each region in a water maze test after intracerebroventricular administration of the ADEL-Y01m antibody to a dementia mouse model (**p<0.01).

FuncS

Figure 5 is a graph showing the results of a grip strength test after administration of ADEL-Y01m antibody to a mouse model of ventricular dementia (*p<0.05, **p<0.01).

FuncS

Figure 6 is a graph showing the nested test results after intraperitoneal administration of ADEL-Y01m antibody to a dementia mouse model (*p<0.05, **p<0.01).

FuncS

Figure 7 is a graph showing the results of a Y-maze test after intraperitoneal administration of ADEL-Y01m antibody to a dementia mouse model (*p<0.05).

FuncS

Figure 8 is a graph showing the results of an underwater maze test after intraperitoneal administration of ADEL-Y01m antibody to a dementia mouse model.

IHC

Figure 9 is a photo of immunohistochemical staining of normal aged brain tissue and Alzheimer's disease patient brain tissue with ADEL-Y01m antibody.

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