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Creative Biolabs
Product

NeuroMab™ Anti-Tau (K280-ac) BBB Shuttle Antibody, Clone ADEL-Y01m

[CAT#: NRZP-1022-ZP3123]

Host Species:
Mouse
Species Reactivity:
Human; Mouse
Applications:
ELISA; Block; Inhib; In Vitro; In Vivo

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Clone Number

ADEL-Y01m

Applications

ELISA; Block; Inhib; In Vitro; In Vivo
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

Tau (K280-ac)

Alternative Names

MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40; phosphorylated tau
Product Pictures
FuncS

Figure 1 is a graph showing the results of a nesting test after administration of ADEL-Y01m antibody to a mouse model of ventricular dementia (***p<0.001).

FuncS

Figure 2 is a graph showing the results of Y-maze test after intracerebroventricular administration of ADEL-Y01m antibody to a dementia mouse model (*p<0.05).

FuncS

Figure 3 is a graph showing the results of a water maze test after administration of an ADEL-Y01m antibody to a mouse model of ventricular dementia.

FuncS

Figure 4 is a graph showing the residence time in each region in a water maze test after intracerebroventricular administration of the ADEL-Y01m antibody to a dementia mouse model (**p<0.01).

FuncS

Figure 5 is a graph showing the results of a grip strength test after administration of ADEL-Y01m antibody to a mouse model of ventricular dementia (*p<0.05, **p<0.01).

FuncS

Figure 6 is a graph showing the nested test results after intraperitoneal administration of ADEL-Y01m antibody to a dementia mouse model (*p<0.05, **p<0.01).

FuncS

Figure 7 is a graph showing the results of a Y-maze test after intraperitoneal administration of ADEL-Y01m antibody to a dementia mouse model (*p<0.05).

FuncS

Figure 8 is a graph showing the results of an underwater maze test after intraperitoneal administration of ADEL-Y01m antibody to a dementia mouse model.

IHC

Figure 9 is a photo of immunohistochemical staining of normal aged brain tissue and Alzheimer's disease patient brain tissue with ADEL-Y01m antibody.

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For Research Use Only. Not For Clinical Use.
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