Product
Human Superoxide dismutase 1, Over-expression soluble Adenovirus
[CAT#: NV-2106-P09]
- Target:
- SOD1
- Type:
- Expression Vector
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Overview
Species
Human
Type
Expression Vector
Virus Type
AV
Promoter
CMV (ubiquitous)
Application Notes
The superoxide dismutase family is composed of three metalloenzymes (SOD-1, SOD-2 and SOD-3) that catalyze the oxido-reduction of reactive oxygen species (ROS) such as superoxide anion. Unlike SOD-1, which is a homodimeric cytosolic Cu-Zn enzyme, SOD-2 is a 22 kDa homotetrameric manganese enzyme (also known as MnSOD) that functions in the mitochondrion. SOD-1 activity depends on the delivery of copper cofactors by Copper chaperone for SOD-1 (CCS). CCS prevents copper ions from binding to intracellular scavengers, thus securing copper for SOD-1.
Properties
Soluble In
DMEM, 2% BSA, 2.5% Glycerol
Shipping
Shipped at 4 °C.
Storage
Store lyophilized plasmid/DNA/RNA at -20 °C with desiccant. Stable for one year. Once resuspended, store at 4 °C for short term storage or -80 °C for long term storage. Avoid repeated freeze/thaw cycles.
Quality Control
The sequence of the product is guaranteed by sequencing.
Research Use Only
This product is for research use only.
Target Details
Target
SOD1
Official Name
SOD1
Full Name
superoxide dismutase 1
Alternative Names
SOD1; ALS; ALS1; HEL-S-44; IPOA; SOD; hSod1; homodimer; superoxide dismutase 1; soluble; superoxide dismutase 1; STAHP
References
1. Shuvaev VV, etc (2013). Anti-Inflammatory Effect of Targeted Delivery of SOD to Endothelium: Mechanism, Synergism with NO Donors and Protective Effects In Vitro and In Vivo. PLoS ONE.
2. Sabyasachi Se, etc (2015). Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improve glucose tolerance in an obese diabetic mouse model. Stem Cell Research & Therapy.
3. Han J, etc (2011). Catalase and Superoxide Dismutase Conjugated with Platelet-Endothelial Cell Adhesion Molecule Antibody Distinctly Alleviate Abnormal Endothelial Permeability Caused by Exogenous Reactive Oxygen Species and Vascular Endothelial Growth Factor. Journal of Pharmacology.
4. Ursula A, etc (2011). Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells. FASEB Journal.
2. Sabyasachi Se, etc (2015). Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improve glucose tolerance in an obese diabetic mouse model. Stem Cell Research & Therapy.
3. Han J, etc (2011). Catalase and Superoxide Dismutase Conjugated with Platelet-Endothelial Cell Adhesion Molecule Antibody Distinctly Alleviate Abnormal Endothelial Permeability Caused by Exogenous Reactive Oxygen Species and Vascular Endothelial Growth Factor. Journal of Pharmacology.
4. Ursula A, etc (2011). Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells. FASEB Journal.
Publications
Publications (0)
Neural Antibodies
Neural Genes
Kits
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
