NeuroMab™ Anti-SOD1 BBB Shuttle Antibody, Clone NI-204.12G7
- Host Species:
- Human
- Species Reactivity:
- Human
- Applications:
- ELISA; FC; IHC; In Vitro; In Vivo
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Fig.1 binding specificity of the human antibodies to human recombinant SOD1.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates from PDAPP mouse brain tissue. IgG was used as a negative control in this experiment because it is unable to bind Aβ and therefore cannot induce phagocytosis.
Fig.3 The antibody binds preferentially to misfolded / aggregated human SOD1.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates from PDAPP mouse brain tissue. IgG was used as a negative control in this experiment because it is unable to bind Aβ and therefore cannot induce phagocytosis.
Fig.2 binding specificity of the human antibodies to human recombinant SOD1.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates from PDAPP mouse brain tissue. IgG was used as a negative control in this experiment because it is unable to bind Aβ and therefore cannot induce phagocytosis.
Fig.4 NI-204.12G7 shows a prominent staining of SOD1 pathology, including cytoplasmic SOD1 inclusions, mainly in motor neurons, and extracellular SOD1 aggregates.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates from PDAPP mouse brain tissue. IgG was used as a negative control in this experiment because it is unable to bind Aβ and therefore cannot induce phagocytosis.
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